OBJECTIVES: Eumycetoma caused by Madurella mycetomatis is treated with surgery and high doses of itraconazole and ketoconazole. These agents are toxic, and new therapies are required. METHODS: MICs were determined for artemisinin and tea tree oil, two natural herbal compounds. RESULTS: Artemisinin was not active against M. mycetomatis, but tea tree oil did inhibit its growth. Since tea tree oil's prime component easily penetrates the skin, tea tree oil could be a useful agent in the treatment of eumycetoma. CONCLUSIONS: Tea tree oil is active in vitro against M. mycetomatis.
OBJECTIVES:Eumycetoma caused by Madurella mycetomatis is treated with surgery and high doses of itraconazole and ketoconazole. These agents are toxic, and new therapies are required. METHODS: MICs were determined for artemisinin and tea tree oil, two natural herbal compounds. RESULTS:Artemisinin was not active against M. mycetomatis, but tea tree oil did inhibit its growth. Since tea tree oil's prime component easily penetrates the skin, tea tree oil could be a useful agent in the treatment of eumycetoma. CONCLUSIONS:Tea tree oil is active in vitro against M. mycetomatis.
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