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Literature DB >> 173244

Urinary 3'5' cyclic AMP. Diagnostic test in pseudohypoparathyroidism.

Abstract

Measurement of urinary cyclic AMP (adenosine 3'5'-cyclic phosphate) and examination of calcium and phosphorus metabolism was carried out in two children with pseudohypoparathyroidism. In both patients infusion of parathyroid hormone failed to elicit any change in urinary cyclic AMP, while a dose-dependent increase in urinary cyclic AMP occurred in a normal control. The findings agree with concept of unresponsiveness of renal cortical tissue to parathyroid hormone in pseudohypoparathyroidism and provide further evidence that measurement of urinary cyclic AMP during parathyroid hormone infusion may be the method of choice in the diagnosis of this disease.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1975 PMID： 173244 PMCID： PMC1545541 DOI： 10.1136/adc.50.8.656

Source DB: PubMed Journal: Arch Dis Child ISSN： 0003-9888 Impact factor: 3.791

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References

8 in total

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Authors: M E MACGREGOR; T P WHITEHEAD
Journal: Arch Dis Child Date: 1954-10 Impact factor: 3.791

2. Albright's hereditary osteodystrophy comprising pseudohypoparathyroidism and pseudo-pseudohypoparathyroidism. With a report of two cases representing the complete syndrome occurring in successive generations.

Authors: J B MANN; S ALTERMAN; A G HILLS
Journal: Ann Intern Med Date: 1962-02 Impact factor: 25.391

Urinary 3'5' cyclic AMP. Diagnostic test in pseudohypoparathyroidism.

1. Pseudo-hypoparathyroidism; a description of three cases and a critical appraisal of earlier accounts of the disease.

2. Albright's hereditary osteodystrophy comprising pseudohypoparathyroidism and pseudo-pseudohypoparathyroidism. With a report of two cases representing the complete syndrome occurring in successive generations.

Review 3. Clinical studies and applications of cyclic nucleotides.

4. Urinary excretion of adenosine 3',5'-monophosphate and guanosine 3',5'-monophosphate.

5. Pseudohypoparathyroidism. A disease of the second messenger (3',5'-cyclic AMP).

6. Pseudohypoparathyroidism: defective excretion of 3',5'-AMP in response to parathyroid hormone.

7. Effects of parathyroid hormone on plasma and urinary adenosine 3',5'-monophosphate in man.

8. A protein binding assay for adenosine 3':5'-cyclic monophosphate.