UNLABELLED: The Nottingham Prognostic Index (NPI) is a well established and widely used method of predicting survival of operable primary breast cancer. AIMS: Primary: To present the updated survival figures for each NPI Group. Secondary: From the observations to suggest reasons for the reported fall in mortality from breast cancer. METHODS: The NPI is compiled from grade, size and lymph node status of the primary tumour. Consecutive cases diagnosed and treated at Nottingham City Hospital in 1980-1986 (n=892) and 1990-1999 (n=2,238) are compared. Changes in protocols towards earlier diagnosis and better case management were made in the late 1980s between the two data sets. RESULTS: Case survival (Breast Cancer Specific) at 10 years has improved overall from 55% to 77%. Within all Prognostic groups there are high relative and absolute risk reductions. The distribution of cases to Prognostic groups shows only a small increase in the numbers in better groups. CONCLUSION: The updated survival figures overall and for each Prognostic group for the NPI are presented.
UNLABELLED: The Nottingham Prognostic Index (NPI) is a well established and widely used method of predicting survival of operable primary breast cancer. AIMS: Primary: To present the updated survival figures for each NPI Group. Secondary: From the observations to suggest reasons for the reported fall in mortality from breast cancer. METHODS: The NPI is compiled from grade, size and lymph node status of the primary tumour. Consecutive cases diagnosed and treated at Nottingham City Hospital in 1980-1986 (n=892) and 1990-1999 (n=2,238) are compared. Changes in protocols towards earlier diagnosis and better case management were made in the late 1980s between the two data sets. RESULTS: Case survival (Breast Cancer Specific) at 10 years has improved overall from 55% to 77%. Within all Prognostic groups there are high relative and absolute risk reductions. The distribution of cases to Prognostic groups shows only a small increase in the numbers in better groups. CONCLUSION: The updated survival figures overall and for each Prognostic group for the NPI are presented.
Authors: Maura Bríd Cotter; Alex Dakin; Aoife Maguire; Janice M Walshe; M John Kennedy; Barbara Dunne; Ciarán Ó Riain; Cecily M Quinn Journal: Virchows Arch Date: 2017-07-14 Impact factor: 4.064
Authors: P Britton; S W Duffy; R Sinnatamby; M G Wallis; S Barter; M Gaskarth; A O'Neill; C Caldas; J D Brenton; P Forouhi; G C Wishart Journal: Br J Cancer Date: 2009-05-19 Impact factor: 7.640
Authors: Gordon C Wishart; Elizabeth M Azzato; David C Greenberg; Jem Rashbass; Olive Kearins; Gill Lawrence; Carlos Caldas; Paul D P Pharoah Journal: Breast Cancer Res Date: 2010-01-06 Impact factor: 6.466
Authors: Fabien Reyal; Martin H van Vliet; Nicola J Armstrong; Hugo M Horlings; Karin E de Visser; Marlen Kok; Andrew E Teschendorff; Stella Mook; Laura van 't Veer; Carlos Caldas; Remy J Salmon; Marc J van de Vijver; Lodewyk F A Wessels Journal: Breast Cancer Res Date: 2008-11-13 Impact factor: 6.466