| Literature DB >> 17309301 |
Amy E Wright1, Julianne Cook Botelho, Esther Guzmán, Dedra Harmody, Patricia Linley, Peter J McCarthy, Tara P Pitts, Shirley A Pomponi, John K Reed.
Abstract
A new marine-derived macrolide designated as neopeltolide (1) has been isolated from a deep-water sponge of the family Neopeltidae. Its structure was elucidated on the basis of spectroscopic data interpretation. Neopeltolide (1) is a potent inhibitor of the in vitro proliferation of the A-549 human lung adenocarcinoma, the NCI-ADR-RES human ovarian sarcoma, and the P388 murine leukemia cell lines, with IC50's of 1.2, 5.1, and 0.56 nM, respectively. Neopeltolide (1) also inhibited the growth of the fungal pathogen Candida albicans with a minimum inhibitory concentration of 0.62 microg/mL.Entities:
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Year: 2007 PMID： 17309301 DOI： 10.1021/np060597h
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050