Literature DB >> 1730924

Construction of a binding site for human immunodeficiency virus type 1 gp120 in rat CD4.

G A Schockmel1, C Somoza, S J Davis, A F Williams, D Healey.   

Abstract

The human immunodeficiency virus (HIV-1) infects T lymphocytes via an interaction between the virus envelope glycoprotein gp120 and the CD4 antigen of T helper cells. Previous studies demonstrated that mutations in various regions of CD4 domain 1 lead to the loss of gp120 binding. In the present study the gp120 binding site was constructed in rat CD4 by replacing rat with human CD4 sequence. A series of mutants was constructed the best of which bound gp120 with an affinity only twofold less than that of human CD4. The data indicate that the gp120 binding site of human CD4 is constituted by residues 33-58 of domain 1.

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Year:  1992        PMID： 1730924      PMCID： PMC2119094          DOI： 10.1084/jem.175.1.301

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  17 in total

1.  Crystal structure of an HIV-binding recombinant fragment of human CD4.

Authors:  S E Ryu; P D Kwong; A Truneh; T G Porter; J Arthos; M Rosenberg; X P Dai; N H Xuong; R Axel; R W Sweet
Journal:  Nature       Date:  1990-11-29       Impact factor: 49.962

2.  Atomic structure of a fragment of human CD4 containing two immunoglobulin-like domains.

Authors:  J H Wang; Y W Yan; T P Garrett; J H Liu; D W Rodgers; R L Garlick; G E Tarr; Y Husain; E L Reinherz; S C Harrison
Journal:  Nature       Date:  1990-11-29       Impact factor: 49.962

3.  The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain.

Authors:  P J Maddon; A G Dalgleish; J S McDougal; P R Clapham; R A Weiss; R Axel
Journal:  Cell       Date:  1986-11-07       Impact factor: 41.582

4.  Substitution of murine for human CD4 residues identifies amino acids critical for HIV-gp120 binding.

Authors:  L K Clayton; R E Hussey; R Steinbrich; H Ramachandran; Y Husain; E L Reinherz
Journal:  Nature       Date:  1988-09-22       Impact factor: 49.962

5.  Genetic analysis of monoclonal antibody and HIV binding sites on the human lymphocyte antigen CD4.

Authors:  A Peterson; B Seed
Journal:  Cell       Date:  1988-07-01       Impact factor: 41.582

6.  Differences in affinity of anti-CD4 monoclonal antibodies predict their effects on syncytium induction by human immunodeficiency virus.

Authors:  D Wilks; L Walker; J O'Brien; J Habeshaw; A Dalgleish
Journal:  Immunology       Date:  1990-09       Impact factor: 7.397

7.  Binding of HTLV-III/LAV to T4+ T cells by a complex of the 110K viral protein and the T4 molecule.

Authors:  J S McDougal; M S Kennedy; J M Sligh; S P Cort; A Mawle; J K Nicholson
Journal:  Science       Date:  1986-01-24       Impact factor: 47.728

8.  A highly selected panel of anti-CD4 antibodies fails to induce anti-idiotypic antisera mediating human immunodeficiency virus neutralization.

Authors:  D G Healey; L Dianda; D Buck; K Schroeder; A Truneh; Q J Sattentau; P C Beverley
Journal:  Eur J Immunol       Date:  1991-06       Impact factor: 5.532

9.  Peptide and nucleotide sequences of rat CD4 (W3/25) antigen: evidence for derivation from a structure with four immunoglobulin-related domains.

Authors:  S J Clark; W A Jefferies; A N Barclay; J Gagnon; A F Williams
Journal:  Proc Natl Acad Sci U S A       Date:  1987-03       Impact factor: 11.205

10.  Molecular cloning of the CD2 antigen, the T-cell erythrocyte receptor, by a rapid immunoselection procedure.

Authors:  B Seed; A Aruffo
Journal:  Proc Natl Acad Sci U S A       Date:  1987-05       Impact factor: 11.205
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  9 in total

1.  Structural features of nectin-2 (HveB) required for herpes simplex virus entry.

Authors:  W M Martinez; P G Spear
Journal:  J Virol       Date:  2001-11       Impact factor: 5.103

2.  Homolog-scanning mutagenesis reveals poliovirus receptor residues important for virus binding and replication.

Authors:  M E Morrison; Y J He; M W Wien; J M Hogle; V R Racaniello
Journal:  J Virol       Date:  1994-04       Impact factor: 5.103

3.  Peptide ligands to human immunodeficiency virus type 1 gp120 identified from phage display libraries.

Authors:  M Ferrer; S C Harrison
Journal:  J Virol       Date:  1999-07       Impact factor: 5.103

4.  Role of CD4 epitopes outside the gp120-binding site during entry of human immunodeficiency virus type 1.

Authors:  J H Simon; P Stumbles; N Signoret; C Somoza; M Puklavec; Q J Sattentau; A N Barclay; W James
Journal:  J Virol       Date:  1997-02       Impact factor: 5.103

5.  A monoclonal antibody to the CDR-3 region of CD4 inhibits soluble CD4 binding to virions of human immunodeficiency virus type 1.

Authors:  J P Moore
Journal:  J Virol       Date:  1993-06       Impact factor: 5.103

6.  Identification of CD4 and major histocompatibility complex functional peptide sites and their homology with oligopeptides from human immunodeficiency virus type 1 glycoprotein gp120: role in AIDS pathogenesis.

Authors:  J F Zagury; J Bernard; A Achour; A Astgen; A Lachgar; L Fall; C Carelli; W Issing; J P Mbika; O Picard
Journal:  Proc Natl Acad Sci U S A       Date:  1993-08-15       Impact factor: 11.205

7.  CD4-Induced conformational changes in the human immunodeficiency virus type 1 gp120 glycoprotein: consequences for virus entry and neutralization.

Authors:  N Sullivan; Y Sun; Q Sattentau; M Thali; D Wu; G Denisova; J Gershoni; J Robinson; J Moore; J Sodroski
Journal:  J Virol       Date:  1998-06       Impact factor: 5.103

8.  The human immunodeficiency virus gp120 binding site on CD4: delineation by quantitative equilibrium and kinetic binding studies of mutants in conjunction with a high-resolution CD4 atomic structure.

Authors:  U Moebius; L K Clayton; S Abraham; S C Harrison; E L Reinherz
Journal:  J Exp Med       Date:  1992-08-01       Impact factor: 14.307

9.  A rat CD4 mutant containing the gp120-binding site mediates human immunodeficiency virus type 1 infection.

Authors:  J H Simon; C Somoza; G A Schockmel; M Collin; S J Davis; A F Williams; W James
Journal:  J Exp Med       Date:  1993-04-01       Impact factor: 14.307
  9 in total

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