Literature DB >> 17307844

A riboswitch regulates expression of the coenzyme B12-independent methionine synthase in Mycobacterium tuberculosis: implications for differential methionine synthase function in strains H37Rv and CDC1551.

Digby F Warner1, Suzana Savvi, Valerie Mizrahi, Stephanie S Dawes.   

Abstract

We observed vitamin B(12)-mediated growth inhibition of Mycobacterium tuberculosis strain CDC1551. The B(12) sensitivity was mapped to a polymorphism in metH, encoding a coenzyme B(12)-dependent methionine synthase. Vitamin B(12)-resistant suppressor mutants of CDC1551 containing mutations in a B(12) riboswitch upstream of the metE gene, which encodes a B(12)-independent methionine synthase, were isolated. Expression analysis confirmed that the B(12) riboswitch is a transcriptional regulator of metE in M. tuberculosis.

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Year:  2007        PMID： 17307844      PMCID： PMC1855906          DOI： 10.1128/JB.00040-07

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  23 in total

1.  Use of a flexible cassette method to generate a double unmarked Mycobacterium tuberculosis tlyA plcABC mutant by gene replacement.

Authors:  T Parish; N G Stoker
Journal:  Microbiology       Date:  2000-08       Impact factor: 2.777

Review 2.  Gene regulation by riboswitches.

Authors:  Maumita Mandal; Ronald R Breaker
Journal:  Nat Rev Mol Cell Biol       Date:  2004-06       Impact factor: 94.444

3.  Functional and evolutionary genomics of Mycobacterium tuberculosis: insights from genomic deletions in 100 strains.

Authors:  Anthony G Tsolaki; Aaron E Hirsh; Kathryn DeRiemer; Jose Antonio Enciso; Melissa Z Wong; Margaret Hannan; Yves-Olivier L Goguet de la Salmoniere; Kumiko Aman; Midori Kato-Maeda; Peter M Small
Journal:  Proc Natl Acad Sci U S A       Date:  2004-03-15       Impact factor: 11.205

4.  Antibacterial lysine analogs that target lysine riboswitches.

Authors:  Kenneth F Blount; Joy Xin Wang; Jinsoo Lim; Narasimhan Sudarsan; Ronald R Breaker
Journal:  Nat Chem Biol       Date:  2006-12-03       Impact factor: 15.040

5.  Comparative genomics of the vitamin B12 metabolism and regulation in prokaryotes.

Authors:  Dmitry A Rodionov; Alexey G Vitreschak; Andrey A Mironov; Mikhail S Gelfand
Journal:  J Biol Chem       Date:  2003-07-17       Impact factor: 5.157

6.  Ribonucleotide reduction in Mycobacterium tuberculosis: function and expression of genes encoding class Ib and class II ribonucleotide reductases.

Authors:  Stephanie S Dawes; Digby F Warner; Liana Tsenova; Juliano Timm; John D McKinney; Gilla Kaplan; Harvey Rubin; Valerie Mizrahi
Journal:  Infect Immun       Date:  2003-11       Impact factor: 3.441

7.  A glycolipid of hypervirulent tuberculosis strains that inhibits the innate immune response.

Authors:  Michael B Reed; Pilar Domenech; Claudia Manca; Hua Su; Amy K Barczak; Barry N Kreiswirth; Gilla Kaplan; Clifton E Barry
Journal:  Nature       Date:  2004-09-02       Impact factor: 49.962

8.  Regulation of the vitamin B12 metabolism and transport in bacteria by a conserved RNA structural element.

Authors:  Alexey G Vitreschak; Dmitry A Rodionov; Andrey A Mironov; Mikhail S Gelfand
Journal:  RNA       Date:  2003-09       Impact factor: 4.942

9.  Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains.

Authors:  R D Fleischmann; D Alland; J A Eisen; L Carpenter; O White; J Peterson; R DeBoy; R Dodson; M Gwinn; D Haft; E Hickey; J F Kolonay; W C Nelson; L A Umayam; M Ermolaeva; S L Salzberg; A Delcher; T Utterback; J Weidman; H Khouri; J Gill; A Mikula; W Bishai; W R Jacobs; J C Venter; C M Fraser
Journal:  J Bacteriol       Date:  2002-10       Impact factor: 3.490

10.  Genes required for mycobacterial growth defined by high density mutagenesis.

Authors:  Christopher M Sassetti; Dana H Boyd; Eric J Rubin
Journal:  Mol Microbiol       Date:  2003-04       Impact factor: 3.501
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  38 in total

Review 1.  Elemental economy: microbial strategies for optimizing growth in the face of nutrient limitation.

Authors:  Sabeeha S Merchant; John D Helmann
Journal:  Adv Microb Physiol       Date:  2012       Impact factor: 3.517

Review 2.  Mycobacterium tuberculosis in the Face of Host-Imposed Nutrient Limitation.

Authors:  Michael Berney; Linda Berney-Meyer
Journal:  Microbiol Spectr       Date:  2017-06

3.  Structural insights into ligand binding and gene expression control by an adenosylcobalamin riboswitch.

Authors:  Alla Peselis; Alexander Serganov
Journal:  Nat Struct Mol Biol       Date:  2012-10-14       Impact factor: 15.369

Review 4.  New targets and inhibitors of mycobacterial sulfur metabolism.

Authors:  Hanumantharao Paritala; Kate S Carroll
Journal:  Infect Disord Drug Targets       Date:  2013-04

5.  iniBAC induction Is Vitamin B12- and MutAB-dependent in Mycobacterium marinum.

Authors:  Maikel Boot; Marion Sparrius; Kin Ki Jim; Susanna Commandeur; Alexander Speer; Robert van de Weerd; Wilbert Bitter
Journal:  J Biol Chem       Date:  2016-07-29       Impact factor: 5.157

Review 6.  Nutritional immunity: the impact of metals on lung immune cells and the airway microbiome during chronic respiratory disease.

Authors:  Claire Healy; Natalia Munoz-Wolf; Janné Strydom; Lynne Faherty; Niamh C Williams; Sarah Kenny; Seamas C Donnelly; Suzanne M Cloonan
Journal:  Respir Res       Date:  2021-04-29

Review 7.  Emerging applications of riboswitches in chemical biology.

Authors:  Shana Topp; Justin P Gallivan
Journal:  ACS Chem Biol       Date:  2010-01-15       Impact factor: 5.100

8.  Identification and Regulation of Genes for Cobalamin Transport in the Cyanobacterium Synechococcus sp. Strain PCC 7002.

Authors:  Adam A Pérez; Dmitry A Rodionov; Donald A Bryant
Journal:  J Bacteriol       Date:  2016-09-09       Impact factor: 3.490

9.  Complementation of Cobalamin Auxotrophy in Synechococcus sp. Strain PCC 7002 and Validation of a Putative Cobalamin Riboswitch In Vivo.

Authors:  Adam A Pérez; Zhenfeng Liu; Dmitry A Rodionov; Zhongkui Li; Donald A Bryant
Journal:  J Bacteriol       Date:  2016-09-09       Impact factor: 3.490

Review 10.  Use of siRNA molecular beacons to detect and attenuate mycobacterial infection in macrophages.

Authors:  Remo George; Renata Cavalcante; Celso Carvalho; Elyana Marques; Jonathan B Waugh; M Tino Unlap
Journal:  World J Exp Med       Date:  2015-08-20
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