| Literature DB >> 17305398 |
Svenja Röttger1, Per J R Sjöberg, Mats Larhed.
Abstract
A microwave-enhanced copper-catalyzed protocol for N-arylation using water as the solvent is reported. This fast transformation allows the reaction between various amino acids or amino acid esters and a diverse set of substituted aryl bromides in less than 40 min, affording good yields of non-protected N-arylated amino acids with only minor racemization (6% or less). In addition, online ESI-MS and MS/MS analysis were used to "fish-out" an anionic Cu-containing amino acid complex directly from an ongoing N-arylation reaction.Entities:
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Year: 2007 PMID： 17305398 DOI： 10.1021/cc060150r
Source DB: PubMed Journal: J Comb Chem ISSN： 1520-4766