Literature DB >> 17303893

Widespread occurrence of glyceryl ether monooxygenase activity in rat tissues detected by a novel assay.

Ernst R Werner1, Albin Hermetter, Helmut Prast, Georg Golderer, Gabriele Werner-Felmayer.   

Abstract

An assay was set up for glyceryl ether monooxygenase activity in tissue samples using the novel substrate 1-O-pyrenedecyl-sn-glycerol and high-performance liquid chromatographic analysis of reaction mixtures with fluorescence detection, allowing robust detection of enzymatic activity in microgram amounts of tissue homogenates. The activity partially purified from rat liver strictly depended on the presence of a tetrahydropteridine. Tetrahydrobiopterin-dependent glyceryl ether monooxygenase activity was observed in all rat tissues tested except female heart, with highest activities in liver, intestine, and cerebellum. Activity was not uniformly distributed in brain: it was higher in cerebellum than in striatum or cortex. These data demonstrate that tetrahydrobiopterin-dependent glyceryl ether monooxygenase is found not only in liver and the gastrointestinal tract but also in brain and other organs of the rat and provide an additional goal for tetrahydrobiopterin biosynthesis in these organs.

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Year:  2007        PMID： 17303893      PMCID： PMC2851153          DOI： 10.1194/jlr.D600042-JLR200

Source DB:  PubMed          Journal:  J Lipid Res        ISSN： 0022-2275            Impact factor:   5.922


  18 in total

1.  The biocleavage of isomeric glyceryl ethers by soluble liver enzymes in a variety of species.

Authors:  R C Pfleger; C Piantadosi; F Snyder
Journal:  Biochim Biophys Acta       Date:  1967-12-05

2.  Leishmania donovani possess a NADPH-dependent alkylglycerol cleavage enzyme.

Authors:  D Ma; S M Beverley; S J Turco
Journal:  Biochem Biophys Res Commun       Date:  1996-10-23       Impact factor: 3.575

Review 3.  Tetrahydrobiopterin and nitric oxide: mechanistic and pharmacological aspects.

Authors:  Ernst R Werner; Antonius C F Gorren; Regine Heller; Gabriele Werner-Felmayer; Bernd Mayer
Journal:  Exp Biol Med (Maywood)       Date:  2003-12

4.  Sjögren-Larsson syndrome is caused by mutations in the fatty aldehyde dehydrogenase gene.

Authors:  V De Laurenzi; G R Rogers; D J Hamrock; L N Marekov; P M Steinert; J G Compton; N Markova; W B Rizzo
Journal:  Nat Genet       Date:  1996-01       Impact factor: 38.330

5.  A convenient spectrophotometric method for measuring the kinetic parameters of glyceryl-ether monooxygenase (EC 1.14.16.5).

Authors:  B Kosar-Hashemi; W L Armarego
Journal:  Biol Chem Hoppe Seyler       Date:  1993-01

6.  Solubilization and partial characterization of alkylglycerol monooxygenase from rat liver microsomes.

Authors:  T Ishibashi; Y Imai
Journal:  Eur J Biochem       Date:  1983-04-15

7.  A continuous assay for O-alkylglycerol monooxygenase (E.C. 1.14.16.5).

Authors:  J Koetting; C Unger; H Eibl
Journal:  Lipids       Date:  1987-11       Impact factor: 1.880

8.  Glyceryl-ether monooxygenase (EC 1.14.16.5): nature of the glyceryl-ether lipid substrates in aqueous buffer.

Authors:  H Taguchi; B Kosar-Hashemi; B Paal; N Yang; W L Armarego
Journal:  Biol Chem Hoppe Seyler       Date:  1994-05

9.  Dependence of an alkyl glycol-ether monooxygenase activity upon tetrahydropterins.

Authors:  S Kaufman; R J Pollock; G K Summer; A K Das; A K Hajra
Journal:  Biochim Biophys Acta       Date:  1990-08-01

10.  Growth-dependent accumulation of monoalkylglycerol in Madin-Darby canine kidney cells. Evidence for a role in the regulation of protein kinase C.

Authors:  T R Warne; F G Buchanan; M Robinson
Journal:  J Biol Chem       Date:  1995-05-12       Impact factor: 5.157
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  16 in total

1.  Identification of the gene encoding alkylglycerol monooxygenase defines a third class of tetrahydrobiopterin-dependent enzymes.

Authors:  Katrin Watschinger; Markus A Keller; Georg Golderer; Martin Hermann; Manuel Maglione; Bettina Sarg; Herbert H Lindner; Albin Hermetter; Gabriele Werner-Felmayer; Robert Konrat; Nicolas Hulo; Ernst R Werner
Journal:  Proc Natl Acad Sci U S A       Date:  2010-07-19       Impact factor: 11.205

2.  Glyceryl ether monooxygenase resembles aromatic amino acid hydroxylases in metal ion and tetrahydrobiopterin dependence.

Authors:  Katrin Watschinger; Markus A Keller; Albin Hermetter; Georg Golderer; Gabriele Werner-Felmayer; Ernst R Werner
Journal:  Biol Chem       Date:  2009-01       Impact factor: 3.915

3.  Tetrahydrobiopterin and alkylglycerol monooxygenase substantially alter the murine macrophage lipidome.

Authors:  Katrin Watschinger; Markus A Keller; Eileen McNeill; Mohammad T Alam; Steven Lai; Sabrina Sailer; Veronika Rauch; Jyoti Patel; Albin Hermetter; Georg Golderer; Stephan Geley; Gabriele Werner-Felmayer; Robert S Plumb; Giuseppe Astarita; Markus Ralser; Keith M Channon; Ernst R Werner
Journal:  Proc Natl Acad Sci U S A       Date:  2015-02-09       Impact factor: 11.205

Review 4.  Orphan enzymes in ether lipid metabolism.

Authors:  Katrin Watschinger; Ernst R Werner
Journal:  Biochimie       Date:  2012-07-04       Impact factor: 4.079

5.  Studying fatty aldehyde metabolism in living cells with pyrene-labeled compounds.

Authors:  Markus A Keller; Katrin Watschinger; Karsten Lange; Georg Golderer; Gabriele Werner-Felmayer; Albin Hermetter; Ronald J A Wanders; Ernst R Werner
Journal:  J Lipid Res       Date:  2012-04-16       Impact factor: 5.922

6.  Catalytic residues and a predicted structure of tetrahydrobiopterin-dependent alkylglycerol mono-oxygenase.

Authors:  Katrin Watschinger; Julian E Fuchs; Vladimir Yarov-Yarovoy; Markus A Keller; Georg Golderer; Albin Hermetter; Gabriele Werner-Felmayer; Nicolas Hulo; Ernst R Werner
Journal:  Biochem J       Date:  2012-04-01       Impact factor: 3.857

7.  AGMO Inhibitor Reduces 3T3-L1 Adipogenesis.

Authors:  Caroline Fischer; Annett Wilken-Schmitz; Victor Hernandez-Olmos; Ewgenij Proschak; Holger Stark; Ingrid Fleming; Andreas Weigert; Manuela Thurn; Martine Hofmann; Ernst R Werner; Gerd Geisslinger; Ellen Niederberger; Katrin Watschinger; Irmgard Tegeder
Journal:  Cells       Date:  2021-05-01       Impact factor: 7.666

8.  When the genome bluffs: a tandem duplication event during generation of a novel Agmo knockout mouse model fools routine genotyping.

Authors:  Sabrina Sailer; Stefan Coassin; Ernst R Werner; Katrin Watschinger; Katharina Lackner; Caroline Fischer; Eileen McNeill; Gertraud Streiter; Christian Kremser; Manuel Maglione; Catherine M Green; Daniela Moralli; Alexander R Moschen; Markus A Keller; Georg Golderer; Gabriele Werner-Felmayer; Irmgard Tegeder; Keith M Channon; Benjamin Davies
Journal:  Cell Biosci       Date:  2021-03-16       Impact factor: 9.584

Review 9.  Alkylglycerol monooxygenase.

Authors:  Katrin Watschinger; Ernst R Werner
Journal:  IUBMB Life       Date:  2013-02-25       Impact factor: 3.885

10.  Monitoring of fatty aldehyde dehydrogenase by formation of pyrenedecanoic acid from pyrenedecanal.

Authors:  Markus A Keller; Katrin Watschinger; Georg Golderer; Manuel Maglione; Bettina Sarg; Herbert H Lindner; Gabriele Werner-Felmayer; Alessandro Terrinoni; Ronald J A Wanders; Ernst R Werner
Journal:  J Lipid Res       Date:  2009-11-05       Impact factor: 5.922
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