OBJECTIVE: The pathophysiology of catamenial diseases such as epilepsy is unclear. Therefore, we investigated changes in cortical excitability during anovulatory and ovulatory cycles. PATIENTS AND METHODS: Using transcranial magnetic stimulation (TMS), eight healthy women were investigated during anovulatory and 12 during ovulatory cycles. On days 8, -14, -7 and 2 of the cycle, resting motor threshold (RMT), cortical silent period (CSP), intracortical inhibition (ICI) and intracortical facilitation (ICF) were investigated. Repeated-measures analysis of variance (anova) and nonparametric methods were used for statistical analysis. RESULTS: A trend was seen for group by phase interaction regarding ICI (F = 2.5, P = 0.10). ICI varied during anovulatory cycles (median: 51.0% on day 8; 45.3% on day -14, 51.0% on day -7, and 28.6% on day 2; P = 0.040), mainly because of an increased inhibition on day 2. ICI was more pronounced in anovulatory cycles on day -14 (P = 0.021), -7 (P = 0.048) and 2 (P = 0.018) compared to ovulatory women who did not show intraindividual changes (P = 0.56). RMT, CSP and ICF showed no significant changes during anovulatory or ovulatory cycles. CONCLUSIONS: The results suggest fluctuations in cortical excitability during anovulatory cycles, possibly due to the withdrawal of 'excitatory' oestrogens that initiate menses in anovulatory cycles.
RCT Entities:
OBJECTIVE: The pathophysiology of catamenial diseases such as epilepsy is unclear. Therefore, we investigated changes in cortical excitability during anovulatory and ovulatory cycles. PATIENTS AND METHODS: Using transcranial magnetic stimulation (TMS), eight healthy women were investigated during anovulatory and 12 during ovulatory cycles. On days 8, -14, -7 and 2 of the cycle, resting motor threshold (RMT), cortical silent period (CSP), intracortical inhibition (ICI) and intracortical facilitation (ICF) were investigated. Repeated-measures analysis of variance (anova) and nonparametric methods were used for statistical analysis. RESULTS: A trend was seen for group by phase interaction regarding ICI (F = 2.5, P = 0.10). ICI varied during anovulatory cycles (median: 51.0% on day 8; 45.3% on day -14, 51.0% on day -7, and 28.6% on day 2; P = 0.040), mainly because of an increased inhibition on day 2. ICI was more pronounced in anovulatory cycles on day -14 (P = 0.021), -7 (P = 0.048) and 2 (P = 0.018) compared to ovulatory women who did not show intraindividual changes (P = 0.56). RMT, CSP and ICF showed no significant changes during anovulatory or ovulatory cycles. CONCLUSIONS: The results suggest fluctuations in cortical excitability during anovulatory cycles, possibly due to the withdrawal of 'excitatory' oestrogens that initiate menses in anovulatory cycles.
Authors: Prisca R Bauer; Annika A de Goede; William M Stern; Adam D Pawley; Fahmida A Chowdhury; Robert M Helling; Romain Bouet; Stiliyan N Kalitzin; Gerhard H Visser; Sanjay M Sisodiya; John C Rothwell; Mark P Richardson; Michel J A M van Putten; Josemir W Sander Journal: Brain Date: 2018-02-01 Impact factor: 13.501
Authors: Magdalena Sarah Volz; Theresa Sophie Volz; Andre Russowsky Brunoni; João Paulo Vaz Tostes Ribeiro de Oliveira; Felipe Fregni Journal: Neuromodulation Date: 2012-07-03
Authors: Ali Jannati; Mary A Ryan; Harper L Kaye; Melissa Tsuboyama; Alexander Rotenberg Journal: J Clin Neurophysiol Date: 2022-02-01 Impact factor: 2.177