| Literature DB >> 17298000 |
Lei Sun1, Kung-Bin Sung, Claire Dentinger, Barry Lutz, Lienchi Nguyen, Jingwu Zhang, Haoyu Qin, Mineo Yamakawa, Manqiu Cao, Yu Lu, A J Chmura, Jing Zhu, Xing Su, Andrew A Berlin, Selena Chan, Beatrice Knudsen.
Abstract
Composite organic-inorganic nanoparticles (COINs) are novel optical labels for detection of biomolecules. We have previously developed methods to encapsulate COINs and to functionalize them with antibodies. Here we report the first steps toward application of COINs to the detection of proteins in human tissues. Two analytes, PSA and CK18, are detected simultaneously using two different COINs in a direct binding assay, and two different COINs are shown to simultaneously label PSA in tissue samples.Entities:
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Year: 2007 PMID: 17298000 DOI: 10.1021/nl062453t
Source DB: PubMed Journal: Nano Lett ISSN: 1530-6984 Impact factor: 11.189