Literature DB >> 1729692

Specific inflammatory cytokines regulate the expression of human monocyte 15-lipoxygenase.

D J Conrad1, H Kuhn, M Mulkins, E Highland, E Sigal.   

Abstract

Arachidonate 15-lipoxygenase (arachidonate:oxygen 15-oxidoreductase, EC 1.13.11.33) is a lipid-peroxidating enzyme that is implicated in oxidizing low density lipoprotein to its atherogenic form. Monocyte/macrophage 15-lipoxygenase is present in human atherosclerotic lesions. To pursue a basis for induction of the enzyme, which is not present in blood monocytes, the ability of relevant cytokines to regulate its expression was investigated. Interleukin 4 (IL-4), among 16 factors tested, specifically induced 15-lipoxygenase mRNA and protein in cultured human monocytes. Interferon gamma and hydrocortisone inhibited this induction. High-performance liquid chromatography analysis of lipid extracts from IL-4-treated monocytes detected 15-lipoxygenase products esterified to the cellular membrane lipids, indicating enzymatic action on endogenous substrates. Stimulation of IL-4-treated monocytes with calcium ionophore or opsonized zymosan A enhanced the formation of 15-lipoxygenase products. These data identify IL-4 and interferon gamma as physiological regulators of lipoxygenase expression and suggest an important link between 15-lipoxygenase function and the immune/inflammatory response in atherosclerosis as well as other diseases.

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Year:  1992        PMID： 1729692      PMCID： PMC48207          DOI： 10.1073/pnas.89.1.217

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  32 in total

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Journal:  J Biol Chem       Date:  1990-10-25       Impact factor: 5.157

Review 2.  Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity.

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Journal:  N Engl J Med       Date:  1989-04-06       Impact factor: 91.245

Review 3.  Leukotrienes and lipoxins: structures, biosynthesis, and biological effects.

Authors:  B Samuelsson; S E Dahlén; J A Lindgren; C A Rouzer; C N Serhan
Journal:  Science       Date:  1987-09-04       Impact factor: 47.728

4.  A role for endothelial cell lipoxygenase in the oxidative modification of low density lipoprotein.

Authors:  S Parthasarathy; E Wieland; D Steinberg
Journal:  Proc Natl Acad Sci U S A       Date:  1989-02       Impact factor: 11.205

Review 5.  The maturational breakdown of mitochondria in reticulocytes.

Authors:  S M Rapoport; T Schewe
Journal:  Biochim Biophys Acta       Date:  1986-12-22

6.  Enhanced 5-lipoxygenase activity in lung macrophages compared to monocytes from normal subjects.

Authors:  T D Bigby; M J Holtzman
Journal:  J Immunol       Date:  1987-03-01       Impact factor: 5.422

7.  Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.

Authors:  P Chomczynski; N Sacchi
Journal:  Anal Biochem       Date:  1987-04       Impact factor: 3.365

8.  Enzymatic modification of low density lipoprotein by purified lipoxygenase plus phospholipase A2 mimics cell-mediated oxidative modification.

Authors:  C P Sparrow; S Parthasarathy; D Steinberg
Journal:  J Lipid Res       Date:  1988-06       Impact factor: 5.922

9.  Rabbit reticulocyte lipoxygenase catalyzes specific 12(S) and 15(S) oxygenation of arachidonoyl-phosphatidylcholine.

Authors:  J J Murray; A R Brash
Journal:  Arch Biochem Biophys       Date:  1988-09       Impact factor: 4.013

10.  Molecular structure of human lymphocyte receptor for immunoglobulin E.

Authors:  H Kikutani; S Inui; R Sato; E L Barsumian; H Owaki; K Yamasaki; T Kaisho; N Uchibayashi; R R Hardy; T Hirano
Journal:  Cell       Date:  1986-12-05       Impact factor: 41.582
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  96 in total

1.  IL-4 inhibits osteoclast formation through a direct action on osteoclast precursors via peroxisome proliferator-activated receptor gamma 1.

Authors:  A C Bendixen; N K Shevde; K M Dienger; T M Willson; C D Funk; J W Pike
Journal:  Proc Natl Acad Sci U S A       Date:  2001-02-20       Impact factor: 11.205

Review 2.  ALOX15 as a suppressor of inflammation and cancer: Lost in the link.

Authors:  Rui Tian; Xiangsheng Zuo; Jonathan Jaoude; Fei Mao; Jennifer Colby; Imad Shureiqi
Journal:  Prostaglandins Other Lipid Mediat       Date:  2017-01-13       Impact factor: 3.072

Review 3.  Deciphering the role of n-3 polyunsaturated fatty acid-derived lipid mediators in health and disease.

Authors:  Matthew Spite
Journal:  Proc Nutr Soc       Date:  2013-09-02       Impact factor: 6.297

4.  AMP-activated protein kinase suppresses arachidonate 15-lipoxygenase expression in interleukin 4-polarized human macrophages.

Authors:  Dmitry Namgaladze; Ryan G Snodgrass; Carlo Angioni; Nina Grossmann; Nathalie Dehne; Gerd Geisslinger; Bernhard Brüne
Journal:  J Biol Chem       Date:  2015-08-14       Impact factor: 5.157

5.  IL-4 determines eicosanoid formation in dendritic cells by down-regulation of 5-lipoxygenase and up-regulation of 15-lipoxygenase 1 expression.

Authors:  R Spanbroek; M Hildner; A Köhler; A Müller; F Zintl; H Kühn; O Rådmark; B Samuelsson; A J Habenicht
Journal:  Proc Natl Acad Sci U S A       Date:  2001-04-24       Impact factor: 11.205

6.  Differential expression and localization of 12/15 lipoxygenases in adipose tissue in human obese subjects.

Authors:  Anca D Dobrian; David C Lieb; Qian Ma; John W Lindsay; Banumathi K Cole; Kaiwen Ma; Swarup K Chakrabarti; Norine S Kuhn; Stephen D Wohlgemuth; Mark Fontana; Jerry L Nadler
Journal:  Biochem Biophys Res Commun       Date:  2010-11-19       Impact factor: 3.575

7.  STAT-dependent upregulation of 12/15-lipoxygenase contributes to neuronal injury after stroke.

Authors:  Joo Eun Jung; Hulya Karatas; Yu Liu; Ayfer Yalcin; Joan Montaner; Eng H Lo; Klaus van Leyen
Journal:  J Cereb Blood Flow Metab       Date:  2015-07-15       Impact factor: 6.200

8.  Hck is a key regulator of gene expression in alternatively activated human monocytes.

Authors:  Ashish Bhattacharjee; Srabani Pal; Gerald M Feldman; Martha K Cathcart
Journal:  J Biol Chem       Date:  2011-08-30       Impact factor: 5.157

9.  Oxygenation of 1-docosahexaenoyl lysophosphatidylcholine by lipoxygenases; conjugated hydroperoxydiene and dihydroxytriene derivatives.

Authors:  Long Shuang Huang; Mee Ree Kim; Dai-Eun Sok
Journal:  Lipids       Date:  2007-09-19       Impact factor: 1.880

10.  Human 15-lipoxygenase gene promoter: analysis and identification of DNA binding sites for IL-13-induced regulatory factors in monocytes.

Authors:  U Kelavkar; S Wang; A Montero; J Murtagh; K Shah; K Badr
Journal:  Mol Biol Rep       Date:  1998-07       Impact factor: 2.316
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