BACKGROUND AND OBJECTIVES: A novel method to detect tissue-based macrophages using a combination of superparamagnetic iron oxide (SPIO) nanoparticles and differential phase optical coherence tomography (DP-OCT) with an external oscillating magnetic field is reported. STUDY DESIGN/ MATERIAL AND METHODS: Magnetic force acting on iron-laden tissue-based macrophages was varied by applying a sinusoidal current to a solenoid containing a conical iron core that substantially focused and increased magnetic flux density. RESULTS: Nanoparticle motion was detected with DP-OCT, which can detect tissue movement with nanometer resolution. Frequency response of iron-laden tissue movement was twice the modulation frequency since the magnetic force is proportional to the product of magnetic flux density and gradient. CONCLUSIONS: Results of our experiments indicate that DP-OCT can be used to identify tissue-based macrophage when excited by an external focused oscillating magnetic field. (c) 2007 Wiley-Liss, Inc
BACKGROUND AND OBJECTIVES: A novel method to detect tissue-based macrophages using a combination of superparamagnetic iron oxide (SPIO) nanoparticles and differential phase optical coherence tomography (DP-OCT) with an external oscillating magnetic field is reported. STUDY DESIGN/ MATERIAL AND METHODS: Magnetic force acting on iron-laden tissue-based macrophages was varied by applying a sinusoidal current to a solenoid containing a conical iron core that substantially focused and increased magnetic flux density. RESULTS: Nanoparticle motion was detected with DP-OCT, which can detect tissue movement with nanometer resolution. Frequency response of iron-laden tissue movement was twice the modulation frequency since the magnetic force is proportional to the product of magnetic flux density and gradient. CONCLUSIONS: Results of our experiments indicate that DP-OCT can be used to identify tissue-based macrophage when excited by an external focused oscillating magnetic field. (c) 2007 Wiley-Liss, Inc
Authors: Pin-Chieh Huang; Paritosh Pande; Adeel Ahmad; Marina Marjanovic; Darold R Spillman; Boris Odintsov; Stephen A Boppart Journal: IEEE J Sel Top Quantum Electron Date: 2015-12-17 Impact factor: 4.544
Authors: Chao Zhou; Tsung-Han Tsai; Desmond C Adler; Hsiang-Chieh Lee; David W Cohen; Amy Mondelblatt; Yihong Wang; James L Connolly; James G Fujimoto Journal: Opt Lett Date: 2010-03-01 Impact factor: 3.776