| Literature DB >> 17292655 |
Roberto Cilia1, Chiara Siri, Giorgio Marotta, Danilo De Gaspari, Andrea Landi, Claudio B Mariani, Riccardo Benti, Ioannis U Isaias, Francesco Vergani, Gianni Pezzoli, Angelo Antonini.
Abstract
We prospectively evaluated 20 patients with Parkinson's disease (PD) preoperatively and 12 months after subthalamic nucleus-deep brain stimulation (STN-DBS). All patients had clinical (UPDRS III) and neuropsychological evaluations as well as brain perfusion SPECT-ECD. Clinical and cognitive data were compared with 12 matched PD patients who had not undergone surgery. STN-DBS patients improved in motor symptoms and reduced medications but selectively declined in category fluency (p<0.01). No clinical and cognitive changes were found in the control group at follow-up. Worsening fluency was associated with perfusion decrements in left dorsolateral prefrontal cortex, anterior cingulate cortex and ventral caudate nucleus (p<.001).Entities:
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Year: 2007 PMID： 17292655 DOI： 10.1016/j.parkreldis.2006.11.011
Source DB: PubMed Journal: Parkinsonism Relat Disord ISSN： 1353-8020 Impact factor: 4.891