A retrospective on the requirements for gammadelta T-cell development.

Since the discovery of gammadelta T cells two decades ago, considerable effort has been made to understand their developmental program, their antigen specificity, and their contribution to the immune response. In this review, we focus on what is known about gammadelta T-cell development and on the advances that have been made in determining which genes are required. In addition, we compare the genetic requirements for alphabeta and gammadelta T-cell development with the hope of gaining a better picture of the signaling pathways that govern the development of gammadelta lineage cells.