Literature DB >> 17289854

Citius and longius (faster and longer) with no alpha-actinin-3 in skeletal muscles?

Alejandro Lucia1, Jesús Oliván, Félix Gómez-Gallego, Catalina Santiago, Marta Montil, Carl Foster.   

Abstract

The muscle protein alpha-actinin-3 (ACTN3) is normally thought to be expressed in type II muscle fibres and to be necessary for high-power, high-velocity muscle contractions, such as those typically seen in speed/power athletes. The authors report the case of a Spanish elite long jumper (two times Olympian, personal best of 8.26 m) whose genotype for the ACTN3 gene is 577XX (ACTN3 deficient). These data suggest that there might be notable exceptions to the concept that ACTN3 is the "gene for speed".

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Mesh:

Year:  2007        PMID: 17289854      PMCID: PMC2465381          DOI: 10.1136/bjsm.2006.034199

Source DB:  PubMed          Journal:  Br J Sports Med        ISSN: 0306-3674            Impact factor:   13.800


  9 in total

1.  A common nonsense mutation results in alpha-actinin-3 deficiency in the general population.

Authors:  K N North; N Yang; D Wattanasirichaigoon; M Mills; S Easteal; A H Beggs
Journal:  Nat Genet       Date:  1999-04       Impact factor: 38.330

2.  Performance constraints in decathletes.

Authors:  Raoul Van Damme; Robbie S Wilson; Bieke Vanhooydonck; Peter Aerts
Journal:  Nature       Date:  2002-02-14       Impact factor: 49.962

3.  Differential expression of the actin-binding proteins, alpha-actinin-2 and -3, in different species: implications for the evolution of functional redundancy.

Authors:  M Mills; N Yang; R Weinberger; D L Vander Woude; A H Beggs; S Easteal; K North
Journal:  Hum Mol Genet       Date:  2001-06-15       Impact factor: 6.150

Review 4.  Architecture and function in the muscle sarcomere.

Authors:  J M Squire
Journal:  Curr Opin Struct Biol       Date:  1997-04       Impact factor: 6.809

5.  Mitochondrial DNA and ACTN3 genotypes in Finnish elite endurance and sprint athletes.

Authors:  Anna-Kaisa Niemi; Kari Majamaa
Journal:  Eur J Hum Genet       Date:  2005-08       Impact factor: 4.246

6.  ACTN3 genotype in professional endurance cyclists.

Authors:  A Lucia; F Gómez-Gallego; C Santiago; F Bandrés; C Earnest; M Rabadán; J M Alonso; J Hoyos; A Córdova; G Villa; C Foster
Journal:  Int J Sports Med       Date:  2006-04-11       Impact factor: 3.118

7.  ACTN3 genotype is associated with human elite athletic performance.

Authors:  Nan Yang; Daniel G MacArthur; Jason P Gulbin; Allan G Hahn; Alan H Beggs; Simon Easteal; Kathryn North
Journal:  Am J Hum Genet       Date:  2003-07-23       Impact factor: 11.025

Review 8.  A gene for speed? The evolution and function of alpha-actinin-3.

Authors:  Daniel G MacArthur; Kathryn N North
Journal:  Bioessays       Date:  2004-07       Impact factor: 4.345

9.  Optimum take-off techniques and muscle design for long jump.

Authors:  A Seyfarth; R Blickhan; J L Van Leeuwen
Journal:  J Exp Biol       Date:  2000-02       Impact factor: 3.312

  9 in total
  15 in total

Review 1.  Genes and elite athletes: a roadmap for future research.

Authors:  Nir Eynon; Jonatan R Ruiz; José Oliveira; José Alberto Duarte; Ruth Birk; Alejandro Lucia
Journal:  J Physiol       Date:  2011-05-03       Impact factor: 5.182

2.  The GALNTL6 Gene rs558129 Polymorphism Is Associated With Power Performance.

Authors:  Julen Díaz Ramírez; Jesús Álvarez-Herms; Arkaitz Castañeda-Babarro; Jon Larruskain; Xabier Ramírez de la Piscina; Oleg V Borisov; Ekaterina A Semenova; Elena S Kostryukova; Nikolay A Kulemin; Oleg N Andryushchenko; Andrey K Larin; Liliya B Andryushchenko; Edward V Generozov; Ildus I Ahmetov; Adrian Odriozola
Journal:  J Strength Cond Res       Date:  2020-09-16       Impact factor: 3.775

Review 3.  From gene engineering to gene modulation and manipulation: can we prevent or detect gene doping in sports?

Authors:  Giuseppe Fischetto; Stéphane Bermon
Journal:  Sports Med       Date:  2013-10       Impact factor: 11.136

Review 4.  Genetic testing and sports medicine ethics.

Authors:  Michael John McNamee; Arno Müller; Ivo van Hilvoorde; Søren Holm
Journal:  Sports Med       Date:  2009       Impact factor: 11.136

5.  Association of the ACTN3 R577X polymorphism with power athlete status in Russians.

Authors:  Anastasiya M Druzhevskaya; Ildus I Ahmetov; Irina V Astratenkova; Viktor A Rogozkin
Journal:  Eur J Appl Physiol       Date:  2008-05-10       Impact factor: 3.078

6.  Role of muscle mass on sprint performance: gender differences?

Authors:  Jorge Perez-Gomez; German Vicente Rodriguez; Ignacio Ara; Hugo Olmedillas; Javier Chavarren; Juan Jose González-Henriquez; Cecilia Dorado; José A L Calbet
Journal:  Eur J Appl Physiol       Date:  2007-12-15       Impact factor: 3.078

7.  Can the ability to adapt to exercise be considered a talent-and if so, can we test for it?

Authors:  Craig Pickering; John Kiely
Journal:  Sports Med Open       Date:  2017-11-29

8.  The current use, and opinions of elite athletes and support staff in relation to genetic testing in elite sport within the UK.

Authors:  Ian Varley; Seema Patel; Alun G Williams; Philip J Hennis
Journal:  Biol Sport       Date:  2017-10-11       Impact factor: 2.806

9.  The ACTN3 R577X polymorphism across three groups of elite male European athletes.

Authors:  Nir Eynon; Jonatan R Ruiz; Pedro Femia; Vladimir P Pushkarev; Pawel Cieszczyk; Agnieszka Maciejewska-Karlowska; Marek Sawczuk; Dmitry A Dyatlov; Evgeny V Lekontsev; Leonid M Kulikov; Ruth Birk; David J Bishop; Alejandro Lucia
Journal:  PLoS One       Date:  2012-08-16       Impact factor: 3.240

10.  Scientometric analyses of studies on the role of innate variation in athletic performance.

Authors:  Michael P Lombardo; Shadie Emiah
Journal:  Springerplus       Date:  2014-06-24
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