| Literature DB >> 17289386 |
Luca Gentilucci1, Giuliana Cardillo, Federico Squassabia, Alessandra Tolomelli, Santi Spampinato, Antonino Sparta, Monica Baiula.
Abstract
In this paper, we describe the synthesis of a selected library of heterochiral d-Pro-containing RGD-peptidomimetics (RpD) and we investigate the biological activity as inhibitors of fibronectin adhesion to SK-MEL-24 tumor cells. In particular, peptides 4 and 8 showed an IC(50) in the 10(-8)M range. Despite the linear structure, the peptides tend to adopt a folded conformation in a polar environment.Entities:
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Year: 2007 PMID： 17289386 DOI： 10.1016/j.bmcl.2007.01.073
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823