Literature DB >> 1728664

Investigation of TCDD half-life heterogeneity in veterans of Operation Ranch Hand.

J E Michalek1, R C Tripathi, S P Caudill, J L Pirkle.   

Abstract

The half-life of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), the contaminant of Agent Orange, has been recently estimated in 36 members of Operation Ranch Hand, the Air Force unit responsible for the aerial spraying of Agent Orange in Vietnam, as 7.1 yr with a 95% [corrected] confidence interval of 5.8-9.6 yr. We investigated the variability of TCDD half-life with percent body fat in these 36 Ranch Hand veterans who have two TCDD assay results from serum drawn in 1982 and 1987. Using a repeated measures linear model, we found a marginally significant change in half-life with percentage of body fat (p = .09) and no statistically significant change in half-life with relative changes in percentage of body fat from 1982 to 1987 (p = .60).

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Year:  1992        PMID： 1728664     DOI： 10.1080/15287399209531591

Source DB:  PubMed          Journal:  J Toxicol Environ Health        ISSN： 0098-4108


  6 in total

Review 1.  Dioxin-induced changes in epididymal sperm count and spermatogenesis.

Authors:  Warren G Foster; Serena Maharaj-Briceño; Daniel G Cyr
Journal:  Environ Health Perspect       Date:  2010-04       Impact factor: 9.031

2.  A decay model for assessing polybrominated biphenyl exposure among women in the Michigan Long-Term PBB Study.

Authors:  Metrecia L Terrell; Amita K Manatunga; Chanley M Small; Lorraine L Cameron; Julie Wirth; Heidi Michels Blanck; Robert H Lyles; Michele Marcus
Journal:  J Expo Sci Environ Epidemiol       Date:  2008-01-09       Impact factor: 5.563

3.  Determinants of polybrominated biphenyl serum decay among women in the Michigan PBB cohort.

Authors:  H M Blanck; M Marcus; V Hertzberg; P E Tolbert; C Rubin; A K Henderson; R H Zhang
Journal:  Environ Health Perspect       Date:  2000-02       Impact factor: 9.031

4.  Apparent half-lives of dioxins, furans, and polychlorinated biphenyls as a function of age, body fat, smoking status, and breast-feeding.

Authors:  Meghan O'Grady Milbrath; Yvan Wenger; Chiung-Wen Chang; Claude Emond; David Garabrant; Brenda W Gillespie; Olivier Jolliet
Journal:  Environ Health Perspect       Date:  2008-10-03       Impact factor: 9.031

Review 5.  Linking dioxins to diabetes: epidemiology and biologic plausibility.

Authors:  Rene B J Remillard; Nigel J Bunce
Journal:  Environ Health Perspect       Date:  2002-09       Impact factor: 9.031

6.  Half-life of polybrominated biphenyl in human sera.

Authors:  D H Rosen; W D Flanders; A Friede; H E Humphrey; T H Sinks
Journal:  Environ Health Perspect       Date:  1995-03       Impact factor: 9.031
  6 in total

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