Literature DB >> 17277999

Off-target properties of pharmacotherapy and the importance of mechanistic investigations in early clinical phase drug development.

Richard C Becker1.   

Abstract

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Year:  2007        PMID： 17277999     DOI： 10.1007/s11239-006-0007-3

Source DB:  PubMed          Journal:  J Thromb Thrombolysis        ISSN： 0929-5305            Impact factor:   2.300


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  11 in total

Review 1.  Statins and blood coagulation.

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Review 2.  Effects of statins on endothelium and endothelial progenitor cell recruitment.

Authors:  Dirk H Walter; Stefanie Dimmeler; Andreas M Zeiher
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3.  Simvastatin given for 3 days can inhibit thrombin generation and activation of factor V and enhance factor Va inactivation in hypercholesterolemic patients.

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Review 4.  Heme oxygenase-1: a novel drug target for atherosclerotic diseases?

Authors:  Roland Stocker; Mark A Perrella
Journal:  Circulation       Date:  2006-11-14       Impact factor: 29.690

5.  Paclitaxel enhances thrombin-induced endothelial tissue factor expression via c-Jun terminal NH2 kinase activation.

Authors:  Barbara E Stähli; Giovanni G Camici; Jan Steffel; Alexander Akhmedov; Kushiar Shojaati; Michelle Graber; Thomas F Lüscher; Felix C Tanner
Journal:  Circ Res       Date:  2006-06-22       Impact factor: 17.367

6.  Drug-eluting stents: sirolimus and paclitaxel differentially affect cultured cells and injured arteries.

Authors:  Tom J Parry; Ruth Brosius; Rathna Thyagarajan; Demetrius Carter; Dennis Argentieri; Robert Falotico; John Siekierka
Journal:  Eur J Pharmacol       Date:  2005-11-03       Impact factor: 4.432

Review 7.  Risk factors for coronary artery disease, circulating endothelial progenitor cells, and the role of HMG-CoA reductase inhibitors.

Authors:  Carmen Urbich; Stefanie Dimmeler
Journal:  Kidney Int       Date:  2005-05       Impact factor: 10.612

8.  Antiproliferative agents alter vascular plasminogen activator inhibitor-1 expression: a potential prothrombotic mechanism of drug-eluting stents.

Authors:  James A S Muldowney; John R Stringham; Shawn E Levy; Linda A Gleaves; Mesut Eren; Robert N Piana; Douglas E Vaughan
Journal:  Arterioscler Thromb Vasc Biol       Date:  2006-12-07       Impact factor: 8.311

9.  Simvastatin attenuates expression of cytokine-inducible nitric-oxide synthase in embryonic cardiac myoblasts.

Authors:  Rosalinda Madonna; Pericle Di Napoli; Marika Massaro; Alfredo Grilli; Mario Felaco; Alberto De Caterina; Daming Tang; Raffaele De Caterina; Yong-Jian Geng
Journal:  J Biol Chem       Date:  2005-02-10       Impact factor: 5.157

10.  Aspirin protects Caco-2 cells from apoptosis after serum deprivation through the activation of a phosphatidylinositol 3-kinase/AKT/p21Cip/WAF1pathway.

Authors:  Paolo Ricchi; Antonella Di Palma; Tiziana Di Matola; Anna Apicella; Rosaria Fortunato; Raffaele Zarrilli; Angela Maria Acquaviva
Journal:  Mol Pharmacol       Date:  2003-08       Impact factor: 4.436
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  1 in total

1.  Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases.

Authors:  Douglas B Kell
Journal:  BMC Med Genomics       Date:  2009-01-08       Impact factor: 3.063
  1 in total

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