| Literature DB >> 17275964 |
Pavel Arsenyan1, Kira Rubina, Irina Shestakova, Ilona Domracheva.
Abstract
Synthesis and cytotoxic activity of a series of 4-methyl-1,2,3-selenadiazole-5-carboxylic acid amides on human fibrosarcoma HT-1080, mouse hepatoma MG-22A, and mouse fibroblasts 3T3 cell lines are described. The correlation between compound LD(50) and 3T3 fibroblast cell line morphology was shown. In vivo evaluation of amides on mouse sarcoma S-180 confirms high antitumor activity (58-85%).Entities:
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Year: 2007 PMID： 17275964 DOI： 10.1016/j.ejmech.2006.12.004
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514