Literature DB >> 17270183

Preliminary evidence of glycogen synthase kinase 3 beta as a genetic determinant of polycystic ovary syndrome.

Mark O Goodarzi1, Heath J Antoine, Marita Pall, Jinrui Cui, Xiuqing Guo, Ricardo Azziz.   

Abstract

In this study of 352 women with polycystic ovary syndrome (PCOS) and 289 control women, haplotypes spanning the gene for glycogen synthase kinase 3beta (GSK3B) were constructed on the basis of nine single-nucleotide polymorphisms in white and black subjects separately. In each racial group, we observed that a specific, although different, GSK3B haplotype was associated with increased frequency of PCOS, suggesting that GSK3beta contributes to the pathophysiology and inherited basis of PCOS.

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Year:  2007        PMID： 17270183      PMCID： PMC2012940          DOI： 10.1016/j.fertnstert.2006.11.041

Source DB:  PubMed          Journal:  Fertil Steril        ISSN： 0015-0282            Impact factor:   7.329


  25 in total

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