Literature DB >> 17268941

Refill non-adherence to repeat prescriptions leads to treatment gaps or to high extra costs.

Kristin Krigsman1, Arne Melander, Anders Carlsten, Anders Ekedahl, J Lars Nilsson.   

Abstract

OBJECTIVE: To determine the nature and extent of undersupply and the economic consequences of oversupply of medication among non-adherent patients.
METHODS: This study used copies of repeat prescriptions (= multiple dispensations), collected during 1 week in 2002 at 16 Swedish community pharmacies. For patients with a refill adherence below 80%, treatment gaps were defined as the number of days they had no drug available. The cost of drug oversupply (i.e., refill adherence > 120%) was calculated from the prices of the drug packages dispensed.
RESULTS: The number of collected repeat prescriptions was 3,636. The median of treatment gaps among patients with a refill adherence below 80% was 53 days per 90-100 days treatment period and the corresponding median for oversupply was 40 days. The cost of oversupply for exempt patients (i.e., patients who have paid 1,800 SEK (Euro 196; US$ 243) per year for medicines) was 32,000 SEK (Euro 3,500; US$ 4,300) higher than for non-exempt patients. An extrapolation to all Sweden indicates that exemption from charges leads to an additional oversupply of about 142 million SEK (Euro 15 million; US$ 19 million) per year above that of non-exempt patients.
CONCLUSION: Both undersupply and oversupply of prescribed medicines are common in Sweden. Patients with a refill adherence below 80% seem to have less than half of the prescribed treatment available. Oversupply or drug stockpiling occurs more frequently among exempt than among non-exempt patients, and this oversupply leads to high unnecessary costs.

Entities:  

Mesh:

Substances:

Year:  2007        PMID: 17268941     DOI: 10.1007/s11096-005-4797-8

Source DB:  PubMed          Journal:  Pharm World Sci        ISSN: 0928-1231


  18 in total

1.  Compliance with tricyclic antidepressants: the value of four different methods of assessment.

Authors:  C F George; R C Peveler; S Heiliger; C Thompson
Journal:  Br J Clin Pharmacol       Date:  2000-08       Impact factor: 4.335

2.  Effects of user charges on the use of prescription medicines in different socio-economic groups.

Authors:  L Lundberg; M Johannesson; D G Isacson; L Borgquist
Journal:  Health Policy       Date:  1998-05       Impact factor: 2.980

3.  The effect of patient charges on the utilisation of prescription medicines.

Authors:  B O'Brien
Journal:  J Health Econ       Date:  1989-03       Impact factor: 3.883

Review 4.  The assessment of refill compliance using pharmacy records: methods, validity, and applications.

Authors:  J F Steiner; A V Prochazka
Journal:  J Clin Epidemiol       Date:  1997-01       Impact factor: 6.437

5.  Drugs up in smoke: a study of caseated drugs in Sweden.

Authors:  D Isacson; C Olofsson
Journal:  Pharm World Sci       Date:  1999-04

6.  Access to medicines: cost as an influence on the views and behaviour of patients.

Authors:  Ellen I Schafheutle; Karen Hassell; Peter R Noyce; Marjorie C Weiss
Journal:  Health Soc Care Community       Date:  2002-05

7.  Percentage of adherence correlates with the risk of protease inhibitor (PI) treatment failure in HIV-infected patients.

Authors:  J L Casado; R Sabido; M J Perez-Elías; A Antela; J Oliva; F Dronda; B Mejía; J Fortún
Journal:  Antivir Ther       Date:  1999

8.  Gaps in cardiovascular medication taking: the tip of the iceberg.

Authors:  P Rudd; J Ramesh; C Bryant-Kosling; D Guerrero
Journal:  J Gen Intern Med       Date:  1993-12       Impact factor: 5.128

9.  Acetaminophen overuse in the Ohio Medicaid population.

Authors:  Pamela C Heaton; Robert J Cluxton; Charles J Moomaw
Journal:  J Am Pharm Assoc (2003)       Date:  2003 Nov-Dec

10.  Adherence to statin treatment and readmission of patients after myocardial infarction: a six year follow up study.

Authors:  L Wei; J Wang; P Thompson; S Wong; A D Struthers; T M MacDonald
Journal:  Heart       Date:  2002-09       Impact factor: 5.994

View more
  9 in total

1.  Regional variation and adherence to guidelines for drug treatment of asthma.

Authors:  Marianne Heibert Arnlind; Björn Wettermark; Mika Nokela; Paul Hjemdahl; Clas Rehnberg; Eva Wikström Jonsson
Journal:  Eur J Clin Pharmacol       Date:  2009-10-14       Impact factor: 2.953

2.  Medication oversupply in patients with diabetes.

Authors:  Carolyn T Thorpe; Heather Johnson; Anna Legreid Dopp; Joshua M Thorpe; Katie Ronk; Christine M Everett; Mari Palta; David A Mott; Betty Chewning; Loren Schleiden; Maureen A Smith
Journal:  Res Social Adm Pharm       Date:  2014-09-11

3.  Non-adherence to drug therapy and drug acquisition costs in a national population--a patient-based register study.

Authors:  Bo Hovstadius; Göran Petersson
Journal:  BMC Health Serv Res       Date:  2011-11-28       Impact factor: 2.655

4.  Effect of Dual Use of Veterans Affairs and Medicare Part D Drug Benefits on Antihypertensive Medication Supply in a National Cohort of Veterans with Dementia.

Authors:  Carolyn T Thorpe; Walid F Gellad; Maria K Mor; John P Cashy; John R Pleis; Courtney H Van Houtven; Loren J Schleiden; Joseph T Hanlon; Joshua D Niznik; Ronald L Carico; Chester B Good; Joshua M Thorpe
Journal:  Health Serv Res       Date:  2018-10-16       Impact factor: 3.734

5.  Understanding medication oversupply and its predictors in the outpatient departments in Thailand.

Authors:  Piyameth Dilokthornsakul; Nathorn Chaiyakunapruk; Piyarat Nimpitakpong; Napawan Jeanpeerapong; Katechan Jampachaisri; Todd A Lee
Journal:  BMC Health Serv Res       Date:  2014-09-19       Impact factor: 2.655

6.  Adherence to treatment: what is done in Sweden? Practice, education and research.

Authors:  Björn Södergård
Journal:  Pharm Pract (Granada)       Date:  2008-12-15

7.  Gender Based Cognitive Determinants Of Medication Adherence In Older Adults With Chronic Conditions.

Authors:  Hassan Mahmoodi; Fatemah Jalalizad Nahand; Abdolreza Shaghaghi; Shahin Shooshtari; Mohammad Asghari Jafarabadi; Hamid Allahverdipour
Journal:  Patient Prefer Adherence       Date:  2019-10-15       Impact factor: 2.711

8.  Dosing frequency and adherence in chronic psychiatric disease: systematic review and meta-analysis.

Authors:  Goran Medic; Kyoko Higashi; Kavi J Littlewood; Teresa Diez; Ola Granström; René S Kahn
Journal:  Neuropsychiatr Dis Treat       Date:  2013-01-16       Impact factor: 2.570

9.  Medicine possession ratio as proxy for adherence to antiepileptic drugs: prevalence, associations, and cost implications.

Authors:  Karen Jacobs; Marlene Julyan; Martie S Lubbe; Johanita R Burger; Marike Cockeran
Journal:  Patient Prefer Adherence       Date:  2016-04-12       Impact factor: 2.711

  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.