| Literature DB >> 17268854 |
Helena Pinos1, Esperanza Ortega, Beatriz Carrillo, Mari Angeles Pérez-Izquierdo, Paloma Collado.
Abstract
Leptin, a peptide hormone, is secreted by adipose tissue and is crucial to the regulation of feeding behaviour. The present study has shown that both male and female rats which have been undernourished since day six of gestation, show significantly decreased serum leptin levels on postnatal day 12; but when undernourishment continues into adulthood, only males continue to show decreased leptin levels. If nutritional rehabilitation is implemented early enough in males, serum leptin levels recover and nearly reach levels found in control adult males. Undernutrition also has a long term effect on body weight in both sexes, but nutritional rehabilitation leads to some degree of body weight recovery varying with sex and the age at which rehabilitation was implemented. Undernutrition seems to affect different developmental processes in males than in females, with males being more vulnerable than females in so far as long-term effects on serum leptin levels.Entities:
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Year: 2007 PMID： 17268854 DOI： 10.1007/s11064-006-9240-6
Source DB: PubMed Journal: Neurochem Res ISSN： 0364-3190 Impact factor: 3.996