| Literature DB >> 15159169 |
Rexford S Ahima1, Suzette Y Osei.
Abstract
The discovery of leptin was a major breakthrough in our understanding of the role of adipose tissue as a storage and secretory organ. Leptin was initially thought to act mainly to prevent obesity; however, studies have demonstrated profound effects of leptin in the response to fasting, regulation of neuroendocrine and immune systems, hematopoiesis, bone and brain development. This review will focus on the signaling pathways which mediate these diverse effects of leptin in the brain and other physiologic systems. Copyright 2004 Elsevier Inc.Entities:
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Year: 2004 PMID： 15159169 DOI： 10.1016/j.physbeh.2004.02.014
Source DB: PubMed Journal: Physiol Behav ISSN： 0031-9384