Literature DB >> 1726633

Sialyltransferases of developing rat brain.

F Dall'Olio1.   

Abstract

The activity of four different sialyltransferases acting on N- or O-linked chains of glycoproteins was studied in brains of 19 days-old embryos, 1-day-old newborns and adult rats. By using asialofetuin, fetuin and N-acetyllactosamine as acceptors, it has been possible to measure independently the following enzyme activities: CMP-NeuAc:Gal beta 1-3GalNAc alpha(2-3)-sialyltransferase (EC 2.4.99.4), CMP-NeuAc:Gal beta 1-4GlcNAc alpha(2-3)-sialyltransferase (EC 2.4.99.6), CMP-NeuAc:Gal beta 1-4GlcNAc alpha(2-6)-sialyltransferase (EC 2.4.99.1) and CMP-NeuAc:NeuAc alpha 2-3Gal beta 1-3GalNAc alpha(2-6)-sialyltransferase (EC 2.4.99.7). The specific activity of the first three enzymes which act on asialylated acceptors showed a 2.6-fold decrease in a parallel manner after ontogenic development, while the activity of NeuAc alpha 2-3Gal beta 1-3GalNAc alpha(2-6)-sialyltransferase was four times lower in adult than in embryonic brain, showing a stronger dependence on ontogenic development. Despite the higher level of sialyltransferases able to act on glycoproteins, in fetal brain these glycoproteins do not contain a higher amount of sialic acid.

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Year:  1990        PMID： 1726633     DOI： 10.1007/bf01073374

Source DB:  PubMed          Journal:  Glycoconj J        ISSN： 0282-0080            Impact factor:   2.916


  30 in total

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Journal:  Biochem J       Date:  1988-09-01       Impact factor: 3.857

Review 2.  Cell surface glycoconjugates as onco-differentiation markers in hematopoietic cells.

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Journal:  Biochim Biophys Acta       Date:  1985

3.  Differences in the carbohydrate structures of neural cell-adhesion molecules from adult and embryonic chicken brains.

Authors:  J B Rothbard; R Brackenbury; B A Cunningham; G M Edelman
Journal:  J Biol Chem       Date:  1982-09-25       Impact factor: 5.157

4.  High-pressure liquid chromatography of sialic acid-containing oligosaccharides.

Authors:  M L Bergh; P Koppen; D H van den Eijnden
Journal:  Carbohydr Res       Date:  1981-08-01       Impact factor: 2.104

5.  Evidence for an O-glycan sialylation system in brain. Characterization of a beta-galactoside alpha 2,3-sialyltransferase from rat brain regulating the expression of an alpha-N-acetylgalactosaminide alpha 2,6-sialyltransferase activity.

Authors:  H Baubichon-Cortay; P Broquet; P George; P Louisot
Journal:  Eur J Biochem       Date:  1989-06-15

6.  Specific interaction between Lex and Lex determinants. A possible basis for cell recognition in preimplantation embryos and in embryonal carcinoma cells.

Authors:  I Eggens; B Fenderson; T Toyokuni; B Dean; M Stroud; S Hakomori
Journal:  J Biol Chem       Date:  1989-06-05       Impact factor: 5.157

7.  Mild alkaline borohydride treatment of glycoproteins-a method for liberating both N- and O-linked carbohydrate chains.

Authors:  S Ogata; K O Lloyd
Journal:  Anal Biochem       Date:  1982-01-15       Impact factor: 3.365

8.  Expression of UDP-GalNAc:NeuAc alpha 2,3Gal beta-R beta 1,4(GalNAc to Gal) N-acetylgalactosaminyltransferase involved in the synthesis of Sda antigen in human large intestine and colorectal carcinomas.

Authors:  N Malagolini; F Dall'Olio; G Di Stefano; F Minni; D Marrano; F Serafini-Cessi
Journal:  Cancer Res       Date:  1989-12-01       Impact factor: 12.701

9.  Branch specificity of bovine colostrum CMP-sialic acid: Gal beta 1----4GlcNAc-R alpha 2----6-sialyltransferase. Sialylation of bi-, tri-, and tetraantennary oligosaccharides and glycopeptides of the N-acetyllactosamine type.

Authors:  D H Joziasse; W E Schiphorst; D H Van den Eijnden; J A Van Kuik; H Van Halbeek; J F Vliegenthart
Journal:  J Biol Chem       Date:  1987-02-15       Impact factor: 5.157

10.  The effect of mild alkali and alkaline borohydride on the carbohydrate and peptide moieties of fetuin.

Authors:  E F Hounsell; N J Pickering; M S Stoll; A M Lawson; T Feizi
Journal:  Biochem Soc Trans       Date:  1984-08       Impact factor: 5.407
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  1 in total

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Authors:  Kirtan Kaur; Corina Lesseur; Maya A Deyssenroth; Itai Kloog; Joel D Schwartz; Carmen J Marsit; Jia Chen
Journal:  Environ Res       Date:  2022-03-03       Impact factor: 8.431
  1 in total

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