Literature DB >> 17264362

Integrating a MRI scanner with a 6 MV radiotherapy accelerator: impact of the surface orientation on the entrance and exit dose due to the transverse magnetic field.

A J E Raaijmakers1, B W Raaymakers, S van der Meer, J J W Lagendijk.   

Abstract

At the UMC Utrecht, in collaboration with Elekta and Philips Research Hamburg, we are developing a radiotherapy accelerator with integrated MRI functionality. The radiation dose will be delivered in the presence of a lateral 1.5 T field. Although the photon beam is not affected by the magnetic field, the actual dose deposition is done by a cascade of secondary electrons and these electrons are affected by the Lorentz force. The magnetic field causes a reduced build-up distance: because the trajectory of the electrons between collisions is curved, the entrance depth in tissue decreases. Also, at tissue-air interfaces an increased dose occurs due to the so-called electron return effect (ERE): electrons leaving tissue will describe a circular path in air and re-enter the tissue yielding a local dose increase. In this paper the impact of a 1.5 T magnetic field on both the build-up distance and the dose increase due to the ERE will be investigated as a function of the angle between the surface and the incident beam. Monte Carlo simulations demonstrate that in the presence of a 1.5 T magnetic field, the surface dose, the build-up distance and the exit dose depend more heavily on the surface orientation than in the case without magnetic field. This is caused by the asymmetrical pointspread kernel in the presence of 1.5 T and the directional behaviour of the re-entering electrons. Simulations on geometrical phantoms show that ERE dose increase at air cavities can be avoided using opposing beams, also when the air-tissue boundary is not perpendicular to the beam. For the more general case in patient anatomies, more problems may arise. Future work will address the possibilities and limitations of opposing beams in combination with IMRT in a magnetic field.

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Year:  2007        PMID: 17264362     DOI: 10.1088/0031-9155/52/4/005

Source DB:  PubMed          Journal:  Phys Med Biol        ISSN: 0031-9155            Impact factor:   3.609


  23 in total

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2.  Monte Carlo simulations of patient dose perturbations in rotational-type radiotherapy due to a transverse magnetic field: a tomotherapy investigation.

Authors:  Y M Yang; M Geurts; J B Smilowitz; E Sterpin; B P Bednarz
Journal:  Med Phys       Date:  2015-02       Impact factor: 4.071

3.  Feasibility of spinal stereotactic body radiotherapy in Elekta Unity® MR-Linac.

Authors:  Eun Young Han; Manik Aima; Neil Hughes; Tina M Briere; Debra N Yeboa; Pam Castillo; Jihong Wang; Jinzhong Yang; Sastry Vedam
Journal:  J Radiosurg SBRT       Date:  2020

Review 4.  MR-guided radiation therapy: transformative technology and its role in the central nervous system.

Authors:  Yue Cao; Chia-Lin Tseng; James M Balter; Feifei Teng; Hemant A Parmar; Arjun Sahgal
Journal:  Neuro Oncol       Date:  2017-04-01       Impact factor: 12.300

Review 5.  The future of image-guided radiotherapy will be MR guided.

Authors:  Julianne M Pollard; Zhifei Wen; Ramaswamy Sadagopan; Jihong Wang; Geoffrey S Ibbott
Journal:  Br J Radiol       Date:  2017-03-29       Impact factor: 3.039

Review 6.  Biological effects of static magnetic field exposure in the context of MR-guided radiotherapy.

Authors:  Jonathan Kim Mohajer; Andrew Nisbet; Eirini Velliou; Mazhar Ajaz; Giuseppe Schettino
Journal:  Br J Radiol       Date:  2018-10-31       Impact factor: 3.039

7.  Comparison of dose decrement from intrafraction motion for prone and supine prostate radiotherapy.

Authors:  Jeffrey R Olsen; Parag J Parikh; Michael Watts; Camille E Noel; Kenneth W Baker; Lakshmi Santanam; Jeff M Michalski
Journal:  Radiother Oncol       Date:  2012-07-17       Impact factor: 6.280

8.  Relative dosimetry with an MR-linac: Response of ion chambers, diamond, and diode detectors for off-axis, depth dose, and output factor measurements.

Authors:  Daniel J O'Brien; James Dolan; Stefan Pencea; Nicholas Schupp; Gabriel O Sawakuchi
Journal:  Med Phys       Date:  2017-12-21       Impact factor: 4.071

9.  On the accuracy of bulk synthetic CT for MR-guided online adaptive radiotherapy.

Authors:  Davide Cusumano; Lorenzo Placidi; Stefania Teodoli; Luca Boldrini; Francesca Greco; Silvia Longo; Francesco Cellini; Nicola Dinapoli; Vincenzo Valentini; Marco De Spirito; Luigi Azario
Journal:  Radiol Med       Date:  2019-10-08       Impact factor: 3.469

10.  Technical Note: A Monte Carlo study of magnetic-field-induced radiation dose effects in mice.

Authors:  Ashley E Rubinstein; Zhongxing Liao; Adam D Melancon; Michele Guindani; David S Followill; Ramesh C Tailor; John D Hazle; Laurence E Court
Journal:  Med Phys       Date:  2015-09       Impact factor: 4.071

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