Literature DB >> 17263182

Alpha2-adrenoceptor agonists.

Robert D Sanders1, Mervyn Maze.   

Abstract

Alpha2-Adrenoceptor agonists have an immensely diverse utility in peri-operative and critical care medicine. In particular, their application as premedicants, analgesics and hypnotics/sedatives is becoming increasingly popular with delivery to a wide spectrum of patients. The ability of these agents to provide renal, cardiac and neurocognitive protection is only just being realized and requires further study.

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Year:  2007        PMID： 17263182

Source DB:  PubMed          Journal:  Curr Opin Investig Drugs        ISSN： 1472-4472


  14 in total

1.  Sustained increase in α5GABAA receptor function impairs memory after anesthesia.

Authors:  Agnieszka A Zurek; Jieying Yu; Dian-Shi Wang; Sean C Haffey; Erica M Bridgwater; Antonello Penna; Irene Lecker; Gang Lei; Tom Chang; Eric W R Salter; Beverley A Orser
Journal:  J Clin Invest       Date:  2014-11-03       Impact factor: 14.808

Review 2.  General anesthetics and molecular mechanisms of unconsciousness.

Authors:  Stuart A Forman; Victor A Chin
Journal:  Int Anesthesiol Clin       Date:  2008

Review 3.  Are the pharmacology and physiology of α₂ adrenoceptors determined by α₂-heteroreceptors and autoreceptors respectively?

Authors:  Ralf Gilsbach; Lutz Hein
Journal:  Br J Pharmacol       Date:  2012-01       Impact factor: 8.739

4.  Comparative evaluation of dexmedetomidine and esmolol on hemodynamic responses during laparoscopic cholecystectomy.

Authors:  Vinit K Srivastava; Vaishali Nagle; Sanjay Agrawal; Diwakar Kumar; Amit Verma; Sunil Kedia
Journal:  J Clin Diagn Res       Date:  2015-03-01

5.  Effect of dexmedetomidine versus lorazepam on outcome in patients with sepsis: an a priori-designed analysis of the MENDS randomized controlled trial.

Authors:  Pratik P Pandharipande; Robert D Sanders; Timothy D Girard; Stuart McGrane; Jennifer L Thompson; Ayumi K Shintani; Daniel L Herr; Mervyn Maze; E Wesley Ely
Journal:  Crit Care       Date:  2010-03-16       Impact factor: 9.097

Review 6.  Pharmacological profiles of alpha 2 adrenergic receptor agonists identified using genetically altered mice and isobolographic analysis.

Authors:  Carolyn A Fairbanks; Laura S Stone; George L Wilcox
Journal:  Pharmacol Ther       Date:  2009-04-23       Impact factor: 12.310

7.  Clonidine and dexmedetomidine produce antinociceptive synergy in mouse spinal cord.

Authors:  Carolyn A Fairbanks; Kelley F Kitto; H Oanh Nguyen; Laura S Stone; George L Wilcox
Journal:  Anesthesiology       Date:  2009-03       Impact factor: 7.892

8.  Dexmedetomidine provides renoprotection against ischemia-reperfusion injury in mice.

Authors:  Jianteng Gu; Pamela Sun; Hailin Zhao; Helena R Watts; Robert D Sanders; Niccolo Terrando; Peiyuan Xia; Mervyn Maze; Daqing Ma
Journal:  Crit Care       Date:  2011-06-24       Impact factor: 9.097

9.  Pharmacokinetics of dexmedetomidine combined with therapeutic hypothermia in a piglet asphyxia model.

Authors:  M Ezzati; K Broad; G Kawano; S Faulkner; J Hassell; B Fleiss; P Gressens; I Fierens; J Rostami; M Maze; J W Sleigh; B Anderson; R D Sanders; N J Robertson
Journal:  Acta Anaesthesiol Scand       Date:  2014-04-13       Impact factor: 2.105

10.  Dexmedetomidine Inhibits TLR4/NF-κB Activation and Reduces Acute Kidney Injury after Orthotopic Autologous Liver Transplantation in Rats.

Authors:  Hui Yao; Xinjin Chi; Yi Jin; Yiheng Wang; Pinjie Huang; Shan Wu; Zhengyuan Xia; Jun Cai
Journal:  Sci Rep       Date:  2015-11-20       Impact factor: 4.379
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