Role of SPARC--matricellular protein in pathophysiology and tissue injury healing. Implications for gastritis and gastric ulcers.

In this paper we reviewed roles of SPARC in cell functions with a focus on tissue injury healing. SPARC (Secreted Protein, Acidic and Rich in Cysteine) is a matrix-associated glycoprotein that influences a variety of cellular activities in vitro and in vivo. SPARC and its related peptides bind to several proteins of the extracellular matrix (ECM), affect ECM protein expression, alter cell shape, reduce cellular adhesion, influence migration, and modulate growth factor-induced cell proliferation and angiogenesis. SPARC influences cell interactions with the extracellular milieu during embryonic development and in response to tissue injury. This paper reviews the roles of SPARC in the cellular and molecular events taking place during healing of tissue injury. We also present preliminary data on increased SPARC expression in gastritis and in granulation tissue of human gastric ulcer.