Stephen P Hinshaw1. 1. Department of Psychology, University of California, Berkeley, CA 94720, USA. hinshaw@berkeley.edu
Abstract
OBJECTIVE: To present data on moderators and mediators of treatment response from the Multimodal Treatment Study of Children With ADHD (MTA). METHODS: Moderator variables (baseline factors that define subgroups with greater vs lesser intervention response) and mediator variables (factors occurring during treatment that explain how interventions "work") are described with specific application to the outcomes of the MTA Study. RESULTS: Key moderator variables (comorbid anxiety disorder, public assistance, severity of attention-deficit/hyperactivity disorder, parental depressive symptomatology, IQ) and mediator processes (negative/ineffective parental discipline) are reviewed. CONCLUSIONS: Treatment research in the future should explicitly consider the exploration of moderator and mediator variables, which can greatly aid the explanatory power of clinical trials and specify the critical next steps for intervention research.
OBJECTIVE: To present data on moderators and mediators of treatment response from the Multimodal Treatment Study of Children With ADHD (MTA). METHODS: Moderator variables (baseline factors that define subgroups with greater vs lesser intervention response) and mediator variables (factors occurring during treatment that explain how interventions "work") are described with specific application to the outcomes of the MTA Study. RESULTS: Key moderator variables (comorbid anxiety disorder, public assistance, severity of attention-deficit/hyperactivity disorder, parental depressive symptomatology, IQ) and mediator processes (negative/ineffective parental discipline) are reviewed. CONCLUSIONS: Treatment research in the future should explicitly consider the exploration of moderator and mediator variables, which can greatly aid the explanatory power of clinical trials and specify the critical next steps for intervention research.
Authors: Tanya E Froehlich; Tanya N Antonini; William B Brinkman; Joshua M Langberg; John O Simon; Ryan Adams; Bridget Fredstrom; Megan E Narad; Kathleen M Kingery; Mekibib Altaye; Heather Matheson; Leanne Tamm; Jeffery N Epstein Journal: J Dev Behav Pediatr Date: 2014 Feb-Mar Impact factor: 2.225
Authors: Cristan A Farmer; Nicole V Brown; Kenneth D Gadow; L Eugene Arnold; David G Kolko; Robert L Findling; Brooke S G Molina; Kristin A Buchan-Page; Robert R Rice; Srihari S Bangalore; Oscar Bukstein; E Victoria Rundberg-Rivera; Nora McNamara; Michael G Aman Journal: J Child Adolesc Psychopharmacol Date: 2015-04 Impact factor: 2.576
Authors: Christine L Karver; Shari L Wade; Amy Cassedy; H Gerry Taylor; Tanya M Brown; Michael W Kirkwood; Terry Stancin Journal: Child Neuropsychol Date: 2013-05-28 Impact factor: 2.500
Authors: Denise A Chavira; Ann Garland; May Yeh; Kristen McCabe; Richard L Hough Journal: J Behav Health Serv Res Date: 2008-08-08 Impact factor: 1.505
Authors: Ann Vander Stoep; Carolyn A McCarty; Chuan Zhou; Carol M Rockhill; Erin N Schoenfelder; Kathleen Myers Journal: J Abnorm Child Psychol Date: 2017-01