OBJECTIVE: To evaluate the hypothesis that pretreatment with estrogens in women affected by premature ovarian failure (POF) may improve the results of ovarian stimulation. DESIGN: Double-blind, randomized, placebo-controlled study. SETTING: Outpatient department in an academic research environment. PATIENT(S): Fifty women with POF seeking pregnancy. INTERVENTION(S): Before starting ovarian stimulation, group 1 received 0.05 mg ethinyl-E(2) (EE) three times a day for 2 weeks, while group 2 received placebo. Ovarian stimulation was carried out with recombinant FSH (r-betaFSH), 200 IU/day/SC. Both EE and placebo were administered during ovarian stimulation. Human chorionic gonadotropin (10,000 IU/IM) was added when the follicle exceeded a mean diameter of 18 mm. MAIN OUTCOME MEASURE: Rate of ovulation in women with POF. RESULT(S): Levels of FSH before stimulation were significantly lower in group 1 than in group 2. The rate of ovulation in group 1 (8/25; 32%) was significantly higher than in group 2 (0/25; 0%). Notably, induction of ovulation was successful only in patients whose FSH levels after EE treatment were < or =15 mIU/mL. CONCLUSION(S): Our data suggest that pretreatment with EE improves the success of rate of ovulation induction with exogenous gonadotropins in patients with POF. A threshold of FSH < or =15 mIU/mL should be achieved before starting ovarian stimulation.
RCT Entities:
OBJECTIVE: To evaluate the hypothesis that pretreatment with estrogens in women affected by premature ovarian failure (POF) may improve the results of ovarian stimulation. DESIGN: Double-blind, randomized, placebo-controlled study. SETTING:Outpatient department in an academic research environment. PATIENT(S): Fifty women with POF seeking pregnancy. INTERVENTION(S): Before starting ovarian stimulation, group 1 received 0.05 mg ethinyl-E(2) (EE) three times a day for 2 weeks, while group 2 received placebo. Ovarian stimulation was carried out with recombinant FSH (r-betaFSH), 200 IU/day/SC. Both EE and placebo were administered during ovarian stimulation. Human chorionic gonadotropin (10,000 IU/IM) was added when the follicle exceeded a mean diameter of 18 mm. MAIN OUTCOME MEASURE: Rate of ovulation in women with POF. RESULT(S): Levels of FSH before stimulation were significantly lower in group 1 than in group 2. The rate of ovulation in group 1 (8/25; 32%) was significantly higher than in group 2 (0/25; 0%). Notably, induction of ovulation was successful only in patients whose FSH levels after EE treatment were < or =15 mIU/mL. CONCLUSION(S): Our data suggest that pretreatment with EE improves the success of rate of ovulation induction with exogenous gonadotropins in patients with POF. A threshold of FSH < or =15 mIU/mL should be achieved before starting ovarian stimulation.
Authors: Eun Mi Chang; Ji Eun Han; Hyung Jae Won; You Shin Kim; Tae Ki Yoon; Woo Sik Lee Journal: J Assist Reprod Genet Date: 2011-12-08 Impact factor: 3.412
Authors: Sara Pinelli; Paolo Giovanni Artini; Stefano Basile; Maria Elena Rosa Obino; Claudia Sergiampietri; Diana Giannarelli; Giovanna Simi; Vito Cela Journal: J Assist Reprod Genet Date: 2017-12-05 Impact factor: 3.412