| Literature DB >> 17258401 |
Behnam Sabayan1, Mansooreh Bagheri, Afshin Borhani Haghighi.
Abstract
Sleep disorders have been described in migraine patients. Among sleep disorders RLS has been reported in up to one-third of migraineurs. Adverse effects of anti migraine therapy by dopamine antagonists can not fully explain this association. Therefore we present the hypothesis that RLS and migraine may have a joint origin. The hypothesis is supported by: (1) the same genetic origin for migraine without aura and RLS in single Italian family on chromosome 14q21; this gene codes survival motor neuron-interacting protein 1 (SIP1) which can play role in both diseases. (2) Correlation of both RLS and migraine with fibromyalgia. (3) Alteration of cortical excitability in both migraine and RLS.Entities:
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Year: 2007 PMID: 17258401 DOI: 10.1016/j.mehy.2006.10.060
Source DB: PubMed Journal: Med Hypotheses ISSN: 0306-9877 Impact factor: 1.538