Zehra Akdag Uzun1, Semiha Kurt2, Hatice Karaer Unaldi3. 1. Yenimahalle Training and Research Hospital, Department of Neurology, Yildirim Beyazit University, Ankara, Turkey. 2. Faculty of Medicine, Department of Neurology, Gaziosmanpasa University, Tokat, Turkey. gsemihakurt@hotmail.com. 3. Department of Neurology, Minasera Aldan Hospital, Ankara, Turkey.
Abstract
OBJECTIVE: In this study, we aimed to investigate restless legs syndrome, depression, frequency of fibromyalgia and possible causes of its frequencies, and the relationships among these synergies and migraine's prodrome, aura, pain, and postdrome symptoms in patients with migraine. SUBJECTS AND METHODS: The study group included 200 patients previously or recently diagnosed with definite migraine and according to International Headache Society criteria and 200 healthy volunteers. All subjects underwent a medical interview to confirm restless legs syndrome and fibromyalgia, and they were asked to complete Beck Depression and Anxiety Inventory and "severity of restless legs syndrome inventory." RESULTS: The frequencies of depressive symptoms and fibromyalgia in the patients with migraine were higher than those of the control group. The mean age of the migraine patients with restless legs syndrome was also higher, and this group had migraine headache for a longer time. There was a statistically significant difference with regard to only generalized anxiety and traveler's distress, which were features of the migraine, between migraine patients with and without restless legs syndrome. Restless legs syndrome was more common in migraine patients with and without aura and in those with nonspecific white matter lesions in the cranial MRI. CONCLUSIONS: In our study, the greater frequency of restless legs syndrome, depressive symptoms, and fibromyalgia in the patients with migraine supports the role of dopamine, which is common to all three disorders. Interviews focused on these problems among migraine patients may help to decide on the best available treatment modality.
OBJECTIVE: In this study, we aimed to investigate restless legs syndrome, depression, frequency of fibromyalgia and possible causes of its frequencies, and the relationships among these synergies and migraine's prodrome, aura, pain, and postdrome symptoms in patients with migraine. SUBJECTS AND METHODS: The study group included 200 patients previously or recently diagnosed with definite migraine and according to International Headache Society criteria and 200 healthy volunteers. All subjects underwent a medical interview to confirm restless legs syndrome and fibromyalgia, and they were asked to complete Beck Depression and Anxiety Inventory and "severity of restless legs syndrome inventory." RESULTS: The frequencies of depressive symptoms and fibromyalgia in the patients with migraine were higher than those of the control group. The mean age of the migrainepatients with restless legs syndrome was also higher, and this group had migraineheadache for a longer time. There was a statistically significant difference with regard to only generalized anxiety and traveler's distress, which were features of the migraine, between migrainepatients with and without restless legs syndrome. Restless legs syndrome was more common in migrainepatients with and without aura and in those with nonspecific white matter lesions in the cranial MRI. CONCLUSIONS: In our study, the greater frequency of restless legs syndrome, depressive symptoms, and fibromyalgia in the patients with migraine supports the role of dopamine, which is common to all three disorders. Interviews focused on these problems among migrainepatients may help to decide on the best available treatment modality.
Entities:
Keywords:
Depressive symptoms; Dopamine; Fibromyalgia; Migraine; Restless legs syndrome
Authors: S Cevoli; M Mochi; C Scapoli; N Marzocchi; G Pierangeli; L A Pini; P Cortelli; P Montagna Journal: Eur J Neurol Date: 2006-09 Impact factor: 6.089