BACKGROUND: Gene expressions of the peripheral leukocytes in depressive patients might reflect the systemic dysfunction of major depression. We determined mRNA expression levels of Histone deacetylase 5 (HDAC5) gene and cyclic AMP response element-binding protein 1 (CREB) gene in the leukocyte of depressive patients. HDAC5 and CREB are reported to be important targets of antidepressants, the latter being located in the downstream of the former in lymphocyte calcium signaling. METHODS: 25 patients with major depression and 25 age- and sex-matched healthy controls were included in this study. Twenty patients were able to be followed up until the 8 week-treatment. The mRNA levels were determined by a quantitative RT-PCR method. RESULT: Levels of HDAC5 and CREB mRNA were significantly higher in drug-free depressive patients than those of controls and the higher mRNA levels decreased to control levels after 8-week paroxetine treatment. There were positive correlation between levels of HDAC5 and CREB. CONCLUSION: Our results suggest the alteration of HDAC5 and CREB gene expression in the systemic pathophysiology of major depression.
BACKGROUND: Gene expressions of the peripheral leukocytes in depressivepatients might reflect the systemic dysfunction of major depression. We determined mRNA expression levels of Histone deacetylase 5 (HDAC5) gene and cyclic AMP response element-binding protein 1 (CREB) gene in the leukocyte of depressivepatients. HDAC5 and CREB are reported to be important targets of antidepressants, the latter being located in the downstream of the former in lymphocyte calcium signaling. METHODS: 25 patients with major depression and 25 age- and sex-matched healthy controls were included in this study. Twenty patients were able to be followed up until the 8 week-treatment. The mRNA levels were determined by a quantitative RT-PCR method. RESULT: Levels of HDAC5 and CREB mRNA were significantly higher in drug-free depressivepatients than those of controls and the higher mRNA levels decreased to control levels after 8-week paroxetine treatment. There were positive correlation between levels of HDAC5 and CREB. CONCLUSION: Our results suggest the alteration of HDAC5 and CREB gene expression in the systemic pathophysiology of major depression.
Authors: Joshua Hyong-Jin Cho; Michael R Irwin; Naomi I Eisenberger; Donald M Lamkin; Steve W Cole Journal: Neuropsychopharmacology Date: 2019-01-14 Impact factor: 7.853
Authors: Andrew F Leuchter; Ian A Cook; Steven P Hamilton; Katherine L Narr; Arthur Toga; Aimee M Hunter; Kym Faull; Julian Whitelegge; Anne M Andrews; Joseph Loo; Baldwin Way; Stanley F Nelson; Steven Horvath; Barry D Lebowitz Journal: Curr Psychiatry Rep Date: 2010-12 Impact factor: 5.285
Authors: John M Hettema; Seon-Sook An; Edwin J C G van den Oord; Michael C Neale; Kenneth S Kendler; Xiangning Chen Journal: Am J Med Genet B Neuropsychiatr Genet Date: 2009-12-05 Impact factor: 3.568