| Literature DB >> 17257842 |
Peter J Crocker1, Anu Mahadevan, Jenny L Wiley, Billy R Martin, Raj K Razdan.
Abstract
A facile synthesis of 1-fluoro-1-deoxy-Delta(8)-THC analogs with side chains seven carbons in length, in the alkane/ene/yne- series (6, 5, and 4), was achieved from 1-fluoro-3,5-dimethoxybenzene (1). In vitro studies show that substitution by a fluorine has a significant detrimental effect on CB1 binding which is supported by in vivo testing. The implications of these results on the SAR of classical cannabinoids are discussed.Entities:
Mesh：
Substances：
Year: 2007 PMID： 17257842 PMCID： PMC1855243 DOI： 10.1016/j.bmcl.2007.01.006
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823