Literature DB >> 16918460

Selective fluorination in drug design and development: an overview of biochemical rationales.

Kenneth L Kirk1.   

Abstract

Several strategies used in the rational design and synthesis of fluorinated compounds as potential therapeutic agents are reviewed. Applications of fluorine substitution in empirical SAR studies for lead development also are discussed, along with the implications with respect to fluorine target interactions that can be derived from biological activities.

Entities:  

Mesh：

Substances：

Year:  2006        PMID： 16918460     DOI： 10.2174/156802606777951073

Source DB:  PubMed          Journal:  Curr Top Med Chem        ISSN： 1568-0266            Impact factor:   3.295


  19 in total

1.  Liquid crystal-related compound-induced cell growth suppression and apoptosis in the chronic myelogenous leukemia K562 cell line.

Authors:  Yukako Fukushi; Masaharu Hazawa; Kenji Takahashi; Atsushi Yoshizawa; Ikuo Kashiwakura
Journal:  Invest New Drugs       Date:  2010-04-27       Impact factor: 3.850

2.  The role of fluorine substitution in the structure-activity relationships (SAR) of classical cannabinoids.

Authors:  Peter J Crocker; Anu Mahadevan; Jenny L Wiley; Billy R Martin; Raj K Razdan
Journal:  Bioorg Med Chem Lett       Date:  2007-01-13       Impact factor: 2.823

3.  A trifluoromethyl analog of verbenachalcone promotes neurite outgrowth and cell proliferation of NeuroScreen-1 cells.

Authors:  Susan Yeyeodu; Nailya Gilyazova; Eun Young Huh; Srinivasa R Dandepally; Carla Oldham; Alfred Williams; Gordon Ibeanu
Journal:  Cell Mol Neurobiol       Date:  2010-09-17       Impact factor: 5.046

4.  Highly efficient diastereoselective reduction of alpha-fluoroimines.

Authors:  Roy M Malamakal; Whitney R Hess; Todd A Davis
Journal:  Org Lett       Date:  2010-05-21       Impact factor: 6.005

5.  Palladium-catalyzed coupling reactions on functionalized 2-trifluoromethyl-4-chromenone scaffolds. Synthesis of highly functionalized trifluoromethyl-heterocycles.

Authors:  Javier Izquierdo; Atul D Jain; Sarki A Abdulkadir; Gary E Schiltz
Journal:  Synthesis (Stuttg)       Date:  2019-03       Impact factor: 3.157

6.  Investigations on the antitumor activity of classical trifluoro-substituted zinc phthalocyanines derivatives.

Authors:  Suhailah S Al-Jameel; Tamer E Youssef
Journal:  World J Microbiol Biotechnol       Date:  2018-03-17       Impact factor: 3.312

7.  A synthetic analog of verbenachalcone potentiates NGF-induced neurite outgrowth and enhances cell survival in neuronal cell models.

Authors:  Ceiléssia M Clement; Srinivasa R Dandepally; Alfred L Williams; Gordon C Ibeanu
Journal:  Neurosci Lett       Date:  2009-05-07       Impact factor: 3.046

8.  New difluoro Knoevenagel condensates of curcumin, their Schiff bases and copper complexes as proteasome inhibitors and apoptosis inducers in cancer cells.

Authors:  Subhash Padhye; Huanjie Yang; Abeda Jamadar; Qiuzhi Cindy Cui; Deepak Chavan; Kristin Dominiak; Jaclyn McKinney; Sanjeev Banerjee; Q Ping Dou; Fazlul H Sarkar
Journal:  Pharm Res       Date:  2009-05-07       Impact factor: 4.200

9.  Synthesis and in vitro cytotoxic evaluation of novel diazaspiro bicyclo hydantoin derivatives in human leukemia cells: a SAR study.

Authors:  C S Ananda Kumar; C V Kavitha; K Vinaya; S B Benaka Prasad; N R Thimmegowda; S Chandrappa; Sathees C Raghavan; K S Rangappa
Journal:  Invest New Drugs       Date:  2008-10-07       Impact factor: 3.850

10.  Full and Partial Agonism of a Designed Enzyme Switch.

Authors:  S Jimmy Budiardjo; Timothy J Licknack; Michael B Cory; Dora Kapros; Anuradha Roy; Scott Lovell; Justin Douglas; John Karanicolas
Journal:  ACS Synth Biol       Date:  2016-07-22       Impact factor: 5.110
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.