| Literature DB >> 17257626 |
Xing Wei1, Xianming Chen, Christine Fontanilla, Liming Zhao, Zhong Liang, Richard Dodel, Hampel Hampel, Martin Farlow, Yansheng Du.
Abstract
Recently, association of an interleukin-1A promoter polymorphism (-889, thymine/thymine (T/T)) with Alzheimer's disease was reported, suggesting that this cytokine may play an important role in disease development. To understand the mechanism underlying the interleukin-1A promoter's role in Alzheimer's disease, a study comparing promoter function of an interleukin-1A polymorphism was performed in the SVG astroglia cell line. The effects of thymine and cytosine on transcriptional activity of the interleukin-1A promoter were analyzed by testing luciferase-reporter activity in transfected SVG cells. Our results demonstrate that cytosine/thymine conversion increases activity of the interleukin-1A promoter in SVG cells. Both sodium salicylate and lovastatin are able to block induced promoter activities in astroglial cells. Induced promoter activity by the polymorphism (T/T) may result in the upregulation of interleukin-1alpha protein and "cytokine cycle" amplification, which may promote disease development.Entities:
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Year: 2006 PMID： 17257626 PMCID： PMC1850933 DOI： 10.1016/j.lfs.2006.12.011
Source DB: PubMed Journal: Life Sci ISSN： 0024-3205 Impact factor: 5.037