Literature DB >> 17255748

Specificity of anti-human leukocyte antigen antibody responses after immunization with Remune, an inactivated HIV-1 vaccine.

Mark Page1, Agatha Ojugo, Nesrina Imami, Gareth Hardy, Frances Gotch, Neil Almond.   

Abstract

Antibody responses against human leukocyte antigen (HLA) classes I and II were detected in HIV-1 infected individuals who received a fixed inactivated HIV-1 (Remune) immunotherapy. The response was specific for HLA-B62 and HLA-DR4 concordant with the host cell line, HUT-78, used in vaccine production. These responses were not detected in HLA-B62 and HLA-DR4-positive individuals indicating that immunotherapy did not break tolerance to self-antigens.

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Year:  2007        PMID： 17255748     DOI： 10.1097/QAD.0b013e328012b873

Source DB:  PubMed          Journal:  AIDS        ISSN： 0269-9370            Impact factor:   4.177


  6 in total

1.  Immunization with recombinant HLA classes I and II, HIV-1 gp140, and SIV p27 elicits protection against heterologous SHIV infection in rhesus macaques.

Authors:  Andreas Mörner; Marianne Jansson; Evelien M Bunnik; Jørgen Schøller; Robert Vaughan; Yufei Wang; David C Montefiori; Nel Otting; Ronald Bontrop; Lesley A Bergmeier; Mahavir Singh; Richard T Wyatt; Hanneke Schuitemaker; Gunnel Biberfeld; Rigmor Thorstensson; Thomas Lehner
Journal:  J Virol       Date:  2011-04-13       Impact factor: 5.103

Review 2.  Inhibition of HIV-1 entry by antibodies: potential viral and cellular targets.

Authors:  S Phogat; R T Wyatt; G B Karlsson Hedestam
Journal:  J Intern Med       Date:  2007-07       Impact factor: 8.989

3.  Alloantigen-based AIDS vaccine: revisiting a "rightfully" discarded promising strategy.

Authors:  Gene M Shearer; Adriano Boasso
Journal:  F1000 Med Rep       Date:  2011-06-01

4.  A phase I, randomized study of combined IL-2 and therapeutic immunisation with antiretroviral therapy.

Authors:  Gareth Ad Hardy; Nesrina Imami; Mark R Nelson; Ann K Sullivan; Ron Moss; Marlén Mi Aasa-Chapman; Brian Gazzard; Frances M Gotch
Journal:  J Immune Based Ther Vaccines       Date:  2007-04-11

5.  Serodeconversion of HIV antibody-positive AIDS patients following treatment with V-1 Immunitor.

Authors:  Orapun Metadilogkul; Vichai Jirathitikal; Aldar S Bourinbaiar
Journal:  J Biomed Biotechnol       Date:  2008-10-28

6.  Complement-mediated virus infectivity neutralisation by HLA antibodies is associated with sterilising immunity to SIV challenge in the macaque model for HIV/AIDS.

Authors:  Mark Page; Ruby Quartey-Papafio; Mark Robinson; Mark Hassall; Martin Cranage; James Stott; Neil Almond
Journal:  PLoS One       Date:  2014-02-14       Impact factor: 3.240
  6 in total

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