| Literature DB >> 17254962 |
Frank I Comer1, Carole A Parent.
Abstract
The molecular mechanisms that integrate cellular polarity with tissue architecture during epithelial morphogenesis are poorly understood. Using a three-dimensional model of epithelial morphogenesis, report that the phosphatase PTEN and phosphatidylinositol (4,5)-bisphosphate [PI(4,5)P2] regulate the GTPase Cdc42 and the kinase aPKC to generate the apical plasma membrane domain and maintain apical-basolateral polarity.Entities:
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Year: 2007 PMID： 17254962 DOI： 10.1016/j.cell.2007.01.010
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582