BACKGROUND: Subclinical hypothyroidism, defined as high serum thyroid-stimulating hormone (TSH) levels and normal serum free-triiodothyronine (fT3) and serum free-thyroxine (fT4) levels, is a common medical problem among the elderly, but it is unclear whether it should be treated with thyroid hormone replacement therapy. METHODS AND RESULTS: A cross-sectional study of 3,607 participants in a community health survey in Suita, in the northern part of Osaka, was performed. Participants were categorized into 5 groups: normal, hyperthyroidism, hypothyroidism, subclinical hypothyroidism, and subclinical hyperthyroidism. The association between each group and various phenotypes was examined, in relation to cardiovascular disease and metabolic syndromes. Serum TSH levels increased and fT3 and fT4 levels decreased with age. A total of 14.6% of subjects aged 70-80 years and 20.1% of subjects aged older than 80 years were classified as having subclinical hypothyroidism. Subclinical hypothyroidism was not associated with glycol-hemoglobin A1c, body mass index, pulse rate, hypertension, total cholesterol, high-density lipoprotein cholesterol or triglyceride levels or intima-media thickness. It was only associated with higher fasting blood glucose and glycol-hemoglobin A1c levels compared with euthyroidism. CONCLUSIONS: The present observation does not support the need for treatment of subclinical hypothyroidism or subclinical hyperthyroidism.
BACKGROUND: Subclinical hypothyroidism, defined as high serum thyroid-stimulating hormone (TSH) levels and normal serum free-triiodothyronine (fT3) and serum free-thyroxine (fT4) levels, is a common medical problem among the elderly, but it is unclear whether it should be treated with thyroid hormone replacement therapy. METHODS AND RESULTS: A cross-sectional study of 3,607 participants in a community health survey in Suita, in the northern part of Osaka, was performed. Participants were categorized into 5 groups: normal, hyperthyroidism, hypothyroidism, subclinical hypothyroidism, and subclinical hyperthyroidism. The association between each group and various phenotypes was examined, in relation to cardiovascular disease and metabolic syndromes. Serum TSH levels increased and fT3 and fT4 levels decreased with age. A total of 14.6% of subjects aged 70-80 years and 20.1% of subjects aged older than 80 years were classified as having subclinical hypothyroidism. Subclinical hypothyroidism was not associated with glycol-hemoglobin A1c, body mass index, pulse rate, hypertension, total cholesterol, high-density lipoprotein cholesterol or triglyceride levels or intima-media thickness. It was only associated with higher fasting blood glucose and glycol-hemoglobin A1c levels compared with euthyroidism. CONCLUSIONS: The present observation does not support the need for treatment of subclinical hypothyroidism or subclinical hyperthyroidism.
Authors: Till Ittermann; Daniel Tiller; Christa Meisinger; Carsten Agger; Matthias Nauck; Rainer Rettig; Albert Hofman; Torben Jørgensen; Allan Linneberg; Jacqueline C M Witteman; Oscar H Franco; Karin H Greiser; Karl Werdan; Angela Döring; Alexander Kluttig; Bruno H C Stricker; Henry Völzke Journal: Thyroid Date: 2013-07-17 Impact factor: 6.568
Authors: L Di Luigi; A Parisi; F Quaranta; F Romanelli; E Tranchita; P Sgrò; P Nardi; G Fattorini; R Cavaliere; F Pigozzi; M D'Armiento; A Lenzi Journal: J Endocrinol Invest Date: 2009-07-17 Impact factor: 4.256
Authors: A P Delitala; F Filigheddu; M Orrù; M AlGhatrif; M Steri; M G Pilia; A Scuteri; M Lobina; M G Piras; G Delitala; E G Lakatta; D Schlessinger; F Cucca Journal: Nutr Metab Cardiovasc Dis Date: 2015-10-21 Impact factor: 4.222
Authors: Eleanor M Simonsick; Anne B Newman; Luigi Ferrucci; Suzanne Satterfield; Tamara B Harris; Nicolas Rodondi; Douglas C Bauer Journal: Arch Intern Med Date: 2009-11-23
Authors: Massimo Giusti; Lorenzo Mortara; Roberta Degrandi; Francesca Cecoli; Michele Mussap; Guido Rodriguez; Diego Ferone; Francesco Minuto Journal: Thyroid Res Date: 2008-09-29