X Fu1, H Xia2, H Mao3, S Zhao3, Z Wang3. 1. Renmin Hospital of Wuhan University, Wuhan, China. 2. Renmin Hospital of Wuhan University, Wuhan, China. 13437111270@163.com. 3. The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Abstract
OBJECTIVE: The purpose of this study was to investigate the effect of glycaemic control on subclinical hypothyroidism (SCH) in Chinese type 2 diabetic patients. METHODS: The study included 476 diabetic patients with SCH admitted for treatment of type 2 diabetes. The controls were selected euthyroid patients with similar characteristics regarding [age, body mass index (BMI), gender, previous hypertension or duration of diabetes, and smoke]. Total cholesterol (TC), LDL cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglyceride (TG), the homeostatic model assessment of insulin resistance ratio (HOMA-IR), fasting plasma glucose, hemoglobin A1c (HbA1c), as well as plasma levels of thyrotrophin, and free thyroxine (FT4) were assessed at baseline and after 6 months of glycaemic control treatment. RESULTS: The LDL-C level and HOMA-IR value were significantly higher in the SCH group. Glycaemic control reduced HOMA-IR, HbA1c, LDL-C, and TG level in patients with SCH. Furthermore, glycaemic control plays a negative effect on thyrotrophin in the SCH group, while this effect was not observed in euthyroid subjects. HbA1c plays a positive correlation with HOMA-IR (r = 0.048, p < 0.001), fasting plasma glucose (r = 0.086, p < 0.001), LDL-C (r = 0.062, p < 0.001) and TG (r = 0.021, p = 0.009). CONCLUSION: Our study shows that glycaemic control may bring some benefits to type 2 diabetic patients with SCH.
OBJECTIVE: The purpose of this study was to investigate the effect of glycaemic control on subclinical hypothyroidism (SCH) in Chinese type 2 diabeticpatients. METHODS: The study included 476 diabeticpatients with SCH admitted for treatment of type 2 diabetes. The controls were selected euthyroid patients with similar characteristics regarding [age, body mass index (BMI), gender, previous hypertension or duration of diabetes, and smoke]. Total cholesterol (TC), LDL cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglyceride (TG), the homeostatic model assessment of insulin resistance ratio (HOMA-IR), fasting plasma glucose, hemoglobin A1c (HbA1c), as well as plasma levels of thyrotrophin, and free thyroxine (FT4) were assessed at baseline and after 6 months of glycaemic control treatment. RESULTS: The LDL-C level and HOMA-IR value were significantly higher in the SCH group. Glycaemic control reduced HOMA-IR, HbA1c, LDL-C, and TG level in patients with SCH. Furthermore, glycaemic control plays a negative effect on thyrotrophin in the SCH group, while this effect was not observed in euthyroid subjects. HbA1c plays a positive correlation with HOMA-IR (r = 0.048, p < 0.001), fasting plasma glucose (r = 0.086, p < 0.001), LDL-C (r = 0.062, p < 0.001) and TG (r = 0.021, p = 0.009). CONCLUSION: Our study shows that glycaemic control may bring some benefits to type 2 diabeticpatients with SCH.
Entities:
Keywords:
Glycaemic control; Subclinical hypothyroidism; Thyrotrophin; Type 2 diabetes mellitus
Authors: P Cettour-Rose; C Theander-Carrillo; C Asensio; M Klein; T J Visser; A G Burger; C A Meier; F Rohner-Jeanrenaud Journal: Diabetologia Date: 2005-03-09 Impact factor: 10.122