Literature DB >> 17251379

Wnt signalling: variety at the core.

Stefan Hoppler1, Claire Louise Kavanagh.   

Abstract

The Wnt/beta-catenin pathway is a conserved cell-cell signalling mechanism in animals that regulates gene expression via TCF/LEF DNA-binding factors to coordinate many cellular processes. Vertebrates normally have four Tcf/Lef genes, which, through alternative splicing and alternative promoter use give rise to a variety of TCF/LEF isoforms. Recent evidence from several experimental systems suggests that this diversity of TCF/LEF factors is functionally important in vertebrates for mediating tissue- and stage-specific Wnt regulation in embryonic development, stem cell differentiation and associated diseases, such as cancer.

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Year:  2007        PMID： 17251379     DOI： 10.1242/jcs.03363

Source DB:  PubMed          Journal:  J Cell Sci        ISSN： 0021-9533            Impact factor:   5.285


  124 in total

1.  Lef1DeltaN binds beta-catenin and increases osteoblast activity and trabecular bone mass.

Authors:  Luke H Hoeppner; Frank J Secreto; David F Razidlo; Tiffany J Whitney; Jennifer J Westendorf
Journal:  J Biol Chem       Date:  2011-01-26       Impact factor: 5.157

Review 2.  Cell-context dependent TCF/LEF expression and function: alternative tales of repression, de-repression and activation potentials.

Authors:  Catherine D Mao; Stephen W Byers
Journal:  Crit Rev Eukaryot Gene Expr       Date:  2011       Impact factor: 1.807

Review 3.  Molecular function of TCF7L2: Consequences of TCF7L2 splicing for molecular function and risk for type 2 diabetes.

Authors:  Ola Hansson; Yuedan Zhou; Erik Renström; Peter Osmark
Journal:  Curr Diab Rep       Date:  2010-12       Impact factor: 4.810

4.  Sequential signaling crosstalk regulates endomesoderm segregation in sea urchin embryos.

Authors:  Aditya J Sethi; Radhika M Wikramanayake; Robert C Angerer; Ryan C Range; Lynne M Angerer
Journal:  Science       Date:  2012-02-03       Impact factor: 47.728

5.  Positive regulation of β-catenin-PROX1 signaling axis by DBC1 in colon cancer progression.

Authors:  E J Yu; S-H Kim; H J Kim; K Heo; C-Y Ou; M R Stallcup; J H Kim
Journal:  Oncogene       Date:  2015-10-19       Impact factor: 9.867

6.  Mouse Tcf3 represses canonical Wnt signaling by either competing for β-catenin binding or through occupation of DNA-binding sites.

Authors:  Nina Solberg; Ondrej Machon; Olga Machonova; Stefan Krauss
Journal:  Mol Cell Biochem       Date:  2012-01-22       Impact factor: 3.396

7.  Regulation of Tcf7 by Runx2 in chondrocyte maturation and proliferation.

Authors:  Masaki Mikasa; Satoshi Rokutanda; Hisato Komori; Kosei Ito; Ying Sze Tsang; Yuki Date; Carolina A Yoshida; Toshihisa Komori
Journal:  J Bone Miner Metab       Date:  2010-10-02       Impact factor: 2.626

8.  MUC1-C oncoprotein induces TCF7L2 transcription factor activation and promotes cyclin D1 expression in human breast cancer cells.

Authors:  Hasan Rajabi; Rehan Ahmad; Caining Jin; Michio Kosugi; Maroof Alam; Maya Datt Joshi; Donald Kufe
Journal:  J Biol Chem       Date:  2012-02-08       Impact factor: 5.157

9.  The type 2 diabetes associated rs7903146 T allele within TCF7L2 is significantly under-represented in Hereditary Multiple Exostoses: insights into pathogenesis.

Authors:  Federica Sgariglia; Elena Pedrini; Jonathan P Bradfield; Tricia R Bhatti; Pio D'Adamo; John P Dormans; Aruni T Gunawardena; Hakon Hakonarson; Jacqueline T Hecht; Luca Sangiorgi; Maurizio Pacifici; Motomi Enomoto-Iwamoto; Struan F A Grant
Journal:  Bone       Date:  2014-12-09       Impact factor: 4.398

Review 10.  H. pylori infection, inflammation and gastric cancer.

Authors:  Qurteeba Qadri; Roohi Rasool; G M Gulzar; Sameer Naqash; Zafar A Shah
Journal:  J Gastrointest Cancer       Date:  2014-06
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