Qurteeba Qadri1, Roohi Rasool, G M Gulzar, Sameer Naqash, Zafar A Shah. 1. Department of Immunology and Molecular Medicine, Sher-i-Kashmir Institute of Medical Sciences (SKIMS), Soura, Srinagar, Jammu and Kashmir, 190011, India, qurteebaqadri@gmail.com.
Abstract
INTRODUCTION: A strong association between chronic infection, inflammation, and cancer has been suggested. DISCUSSION: Helicobacter pylori, a microaerophilic gram negative bacterium, infects about half the world's population. It has been defined as a definitive carcinogen in the pathogenesis of gastric cancer. H. pylori evades the host immune responses and persists in the stomach leading to gastritis gastric atrophy and sometimes gastric cancer. CONCLUSION: Chronic H. pylori infection causes gastric cancer via two mechanisms: the presence of virulence factors and the induction of chronic inflammation which ultimately leads to neoplastic transformation.
INTRODUCTION: A strong association between chronic infection, inflammation, and cancer has been suggested. DISCUSSION: Helicobacter pylori, a microaerophilic gram negative bacterium, infects about half the world's population. It has been defined as a definitive carcinogen in the pathogenesis of gastric cancer. H. pylori evades the host immune responses and persists in the stomach leading to gastritis gastric atrophy and sometimes gastric cancer. CONCLUSION: Chronic H. pyloriinfection causes gastric cancer via two mechanisms: the presence of virulence factors and the induction of chronic inflammation which ultimately leads to neoplastic transformation.
Authors: Guanggang Li; Hasi Wulan; Zongchang Song; Paul A Paik; Ming L Tsao; Gary M Goodman; Paul T MacEachern; Robert S Downey; Anna J Jankowska; Yaron M Rabinowitz; Thomas B Learch; David Z Song; Ji J Yuan; Shihang Zheng; Zhendong Zheng Journal: PLoS One Date: 2015-07-30 Impact factor: 3.240