PURPOSE: The goal of the present study was to evaluate the reproducibility of cerebral A1 adenosine receptor (A1AR) quantification using [18F]CPFPX and PET in a test-retest design. METHODS: Eleven healthy volunteers were studied twice. Eight brain regions ranging from high to low receptor binding were examined. [18F]CPFPX was injected as a bolus with subsequent infusion over 120 min. Various outcome parameters were compared based on either metabolite-corrected venous blood sampling [e.g. apparent equilibrium total distribution volume (DVt')] or a reference region [ratio of specific to non-specific distribution volume (BP2)]. RESULTS: Test-retest variability was low in the outcome measure BP2 (on average 5.9%) and moderate in DVt' (on average 13.2%). Regarding reproducibility, the outcome parameter BP2 showed an intra-class correlation coefficient (ICC) of 0.94 +/- 0.1. For DVt' the between-subject coefficient of variation (%CV) was similar to the within-subject %CV (around 10%), resulting in a poor ICC of 0.06 +/- 0.2. CONCLUSION: Our results suggest that quantification of [18F]CPFPX imaging is reproducible and reliable for PET studies of the cerebral A1AR. Among the outcome parameters the non-invasive measures were of superior test-retest stability over the invasive.
PURPOSE: The goal of the present study was to evaluate the reproducibility of cerebral A1 adenosine receptor (A1AR) quantification using [18F]CPFPX and PET in a test-retest design. METHODS: Eleven healthy volunteers were studied twice. Eight brain regions ranging from high to low receptor binding were examined. [18F]CPFPX was injected as a bolus with subsequent infusion over 120 min. Various outcome parameters were compared based on either metabolite-corrected venous blood sampling [e.g. apparent equilibrium total distribution volume (DVt')] or a reference region [ratio of specific to non-specific distribution volume (BP2)]. RESULTS: Test-retest variability was low in the outcome measure BP2 (on average 5.9%) and moderate in DVt' (on average 13.2%). Regarding reproducibility, the outcome parameter BP2 showed an intra-class correlation coefficient (ICC) of 0.94 +/- 0.1. For DVt' the between-subject coefficient of variation (%CV) was similar to the within-subject %CV (around 10%), resulting in a poor ICC of 0.06 +/- 0.2. CONCLUSION: Our results suggest that quantification of [18F]CPFPX imaging is reproducible and reliable for PET studies of the cerebral A1AR. Among the outcome parameters the non-invasive measures were of superior test-retest stability over the invasive.
Authors: Marcus H Holschbach; Ray A Olsson; Dirk Bier; Walter Wutz; Wiebke Sihver; Manfred Schüller; Bettina Palm; Heinz H Coenen Journal: J Med Chem Date: 2002-11-07 Impact factor: 7.446
Authors: J Noguchi; K Ishiwata; R Furuta; J Simada; M Kiyosawa; S Ishii; K Endo; F Suzuki; M Senda Journal: Nucl Med Biol Date: 1997-01 Impact factor: 2.408
Authors: G S Smith; J C Price; B J Lopresti; Y Huang; N Simpson; D Holt; N S Mason; C C Meltzer; R A Sweet; T Nichols; D Sashin; C A Mathis Journal: Synapse Date: 1998-12 Impact factor: 2.562
Authors: M Laruelle; C van Dyck; A Abi-Dargham; Y Zea-Ponce; S S Zoghbi; D S Charney; R M Baldwin; P B Hoffer; H F Kung; R B Innis Journal: J Nucl Med Date: 1994-05 Impact factor: 10.057
Authors: Andreas Bauer; Marcus H Holschbach; Philipp T Meyer; Christian Boy; Hans Herzog; Ray A Olsson; Heinz H Coenen; Karl Zilles Journal: Neuroimage Date: 2003-08 Impact factor: 6.556
Authors: David Elmenhorst; Eva-Maria Elmenhorst; Eva Hennecke; Tina Kroll; Andreas Matusch; Daniel Aeschbach; Andreas Bauer Journal: Proc Natl Acad Sci U S A Date: 2017-04-03 Impact factor: 11.205
Authors: Min Guo; Zhan-Guo Gao; Ryan Tyler; Tyler Stodden; Yang Li; Joseph Ramsey; Wen-Jing Zhao; Gene-Jack Wang; Corinde E Wiers; Joanna S Fowler; Kenner C Rice; Kenneth A Jacobson; Sung Won Kim; Nora D Volkow Journal: J Med Chem Date: 2018-11-13 Impact factor: 7.446
Authors: Christian Boy; Philipp T Meyer; Gerald Kircheis; Marcus H Holschbach; Hans Herzog; David Elmenhorst; Hans Juergen Kaiser; Heinz H Coenen; Dieter Haussinger; Karl Zilles; Andreas Bauer Journal: Eur J Nucl Med Mol Imaging Date: 2007-11-14 Impact factor: 9.236
Authors: Christa Hohoff; Valentina Garibotto; David Elmenhorst; Anna Baffa; Tina Kroll; Alana Hoffmann; Kathrin Schwarte; Weiqi Zhang; Volker Arolt; Jürgen Deckert; Andreas Bauer Journal: Neuropsychopharmacology Date: 2014-06-19 Impact factor: 7.853