Literature DB >> 17237798

Small-molecule regulation of zebrafish gene expression.

Hanife Esengil1, Vicky Chang, John K Mich, James K Chen.   

Abstract

The zebrafish has emerged as a versatile model organism for biomedical research, yet its potential has been limited by a lack of conditional reverse-genetic tools. Here we report a chemically inducible gene expression technology that has orthogonality to vertebrate signaling processes, high induction levels, and rapid kinetics. Coupled with tissue-specific promoters, this system provides multidimensional control of gene expression and will enable new models of human disorders and diseases.

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Year:  2007        PMID： 17237798     DOI： 10.1038/nchembio858

Source DB:  PubMed          Journal:  Nat Chem Biol        ISSN： 1552-4450            Impact factor:   15.040


  33 in total

1.  Dually inducible TetON systems for tissue-specific conditional gene expression in zebrafish.

Authors:  Franziska Knopf; Kristin Schnabel; Christa Haase; Katja Pfeifer; Konstantinos Anastassiadis; Gilbert Weidinger
Journal:  Proc Natl Acad Sci U S A       Date:  2010-11-01       Impact factor: 11.205

2.  Optimized Gal4 genetics for permanent gene expression mapping in zebrafish.

Authors:  Martin Distel; Mario F Wullimann; Reinhard W Köster
Journal:  Proc Natl Acad Sci U S A       Date:  2009-07-23       Impact factor: 11.205

Review 3.  Chemical technologies for probing embryonic development.

Authors:  Ilya A Shestopalov; James K Chen
Journal:  Chem Soc Rev       Date:  2008-05-07       Impact factor: 54.564

Review 4.  Investigating the genetics of visual processing, function and behaviour in zebrafish.

Authors:  Sabine L Renninger; Helia B Schonthaler; Stephan C F Neuhauss; Ralf Dahm
Journal:  Neurogenetics       Date:  2011-01-26       Impact factor: 2.660

5.  CRISPR/Cas9-mediated conversion of eGFP- into Gal4-transgenic lines in zebrafish.

Authors:  Thomas O Auer; Karine Duroure; Jean-Paul Concordet; Filippo Del Bene
Journal:  Nat Protoc       Date:  2014-11-13       Impact factor: 13.491

6.  Tbx20 drives cardiac progenitor formation and cardiomyocyte proliferation in zebrafish.

Authors:  Fei Lu; Adam Langenbacher; Jau-Nian Chen
Journal:  Dev Biol       Date:  2016-12-08       Impact factor: 3.582

7.  Optogenetic Dissection of Neuronal Circuits in Zebrafish using Viral Gene Transfer and the Tet System.

Authors:  Peixin Zhu; Yuichi Narita; Sebastian T Bundschuh; Otto Fajardo; Yan-Ping Zhang Schärer; Bidisha Chattopadhyaya; Estelle Arn Bouldoires; Anna Ewa Stepien; Karl Deisseroth; Silvia Arber; Rolf Sprengel; Filippo M Rijli; Rainer W Friedrich
Journal:  Front Neural Circuits       Date:  2009-12-11       Impact factor: 3.492

8.  Identification of novel inhibitors of dietary lipid absorption using zebrafish.

Authors:  Justin D Clifton; Edinson Lucumi; Michael C Myers; Andrew Napper; Kotaro Hama; Steven A Farber; Amos B Smith; Donna M Huryn; Scott L Diamond; Michael Pack
Journal:  PLoS One       Date:  2010-08-25       Impact factor: 3.240

9.  A switchable light-input, light-output system modelled and constructed in yeast.

Authors:  Oxana Sorokina; Anita Kapus; Kata Terecskei; Laura E Dixon; Laszlo Kozma-Bognar; Ferenc Nagy; Andrew J Millar
Journal:  J Biol Eng       Date:  2009-09-17       Impact factor: 4.355

10.  Heritable and lineage-specific gene knockdown in zebrafish embryo.

Authors:  Mei Dong; Yan-Fang Fu; Ting-Ting Du; Chang-Bin Jing; Chun-Tang Fu; Yi Chen; Yi Jin; Min Deng; Ting Xi Liu
Journal:  PLoS One       Date:  2009-07-03       Impact factor: 3.240
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