Literature DB >> 17237181

Aeromonas salmonicida toxin AexT has a Rho family GTPase-activating protein domain.

Yael Litvak1, Zvi Selinger.   

Abstract

The N terminus of the Aeromonas salmonicida ADP-ribosylating toxin AexT displays in vitro GTPase-activating protein (GAP) activity for Rac1, CDC42, and RhoA. HeLa cells transfected with the AexT N terminus exhibit rounding and actin disordering. We propose that the Aeromonas salmonicida AexT toxin is a novel member of the growing family of bacterial RhoGAPs.

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Year:  2007        PMID： 17237181      PMCID： PMC1899366          DOI： 10.1128/JB.01358-06

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  13 in total

1.  The N-terminal domain of Pseudomonas aeruginosa exoenzyme S is a GTPase-activating protein for Rho GTPases.

Authors:  U M Goehring; G Schmidt; K J Pederson; K Aktories; J T Barbieri
Journal:  J Biol Chem       Date:  1999-12-17       Impact factor: 5.157

2.  Pseudomonas aeruginosa ExoT is a Rho GTPase-activating protein.

Authors:  R Krall; G Schmidt; K Aktories; J T Barbieri
Journal:  Infect Immun       Date:  2000-10       Impact factor: 3.441

Review 3.  Type III secretion machines: bacterial devices for protein delivery into host cells.

Authors:  J E Galán; A Collmer
Journal:  Science       Date:  1999-05-21       Impact factor: 47.728

4.  Bacterial mimics of eukaryotic GTPase-activating proteins (GAPs).

Authors:  Yael Litvak; Zvi Selinger
Journal:  Trends Biochem Sci       Date:  2003-12       Impact factor: 13.807

5.  Modulation of host signaling by a bacterial mimic: structure of the Salmonella effector SptP bound to Rac1.

Authors:  C E Stebbins; J E Galán
Journal:  Mol Cell       Date:  2000-12       Impact factor: 17.970

6.  Expression of and secretion through the Aeromonas salmonicida type III secretion system.

Authors:  Roger O Ebanks; Leah C Knickle; Michel Goguen; Jessica M Boyd; Devanand M Pinto; Michael Reith; Neil W Ross
Journal:  Microbiology       Date:  2006-05       Impact factor: 2.777

7.  Characterization of an ADP-ribosyltransferase toxin (AexT) from Aeromonas salmonicida subsp. salmonicida.

Authors:  Martin Braun; Katja Stuber; Yvonne Schlatter; Thomas Wahli; Peter Kuhnert; Joachim Frey
Journal:  J Bacteriol       Date:  2002-04       Impact factor: 3.490

8.  The Salmonella typhimurium tyrosine phosphatase SptP is translocated into host cells and disrupts the actin cytoskeleton.

Authors:  Y Fu; J E Galán
Journal:  Mol Microbiol       Date:  1998-01       Impact factor: 3.501

9.  In vivo rho GTPase-activating protein activity of Pseudomonas aeruginosa cytotoxin ExoS.

Authors:  Rebecca Krall; Jianjun Sun; Kristin J Pederson; Joseph T Barbieri
Journal:  Infect Immun       Date:  2002-01       Impact factor: 3.441

10.  GAP activity of the Yersinia YopE cytotoxin specifically targets the Rho pathway: a mechanism for disruption of actin microfilament structure.

Authors:  U Von Pawel-Rammingen; M V Telepnev; G Schmidt; K Aktories; H Wolf-Watz; R Rosqvist
Journal:  Mol Microbiol       Date:  2000-05       Impact factor: 3.501
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  3 in total

Review 1.  Novel bacterial ADP-ribosylating toxins: structure and function.

Authors:  Nathan C Simon; Klaus Aktories; Joseph T Barbieri
Journal:  Nat Rev Microbiol       Date:  2014-07-14       Impact factor: 60.633

Review 2.  Invited review: Small GTPases and their GAPs.

Authors:  Ashwini K Mishra; David G Lambright
Journal:  Biopolymers       Date:  2016-08       Impact factor: 2.505

3.  An In-Silico Sequence-Structure-Function Analysis of the N-Terminal Lobe in CT Group Bacterial ADP-Ribosyltransferase Toxins.

Authors:  Miguel R Lugo; A Rod Merrill
Journal:  Toxins (Basel)       Date:  2019-06-21       Impact factor: 4.546
  3 in total

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