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Literature DB >> 10992524

Pseudomonas aeruginosa ExoT is a Rho GTPase-activating protein.

R Krall¹, G Schmidt, K Aktories, J T Barbieri.

Abstract

Transient intracellular expression of ExoT in CHO cells stimulated cell rounding and actin reorganization. Biochemical studies showed that ExoT was a GTPase-activating protein for RhoA, Rac1, and Cdc42. Together, these data show that ExoT interferes with Rho signal transduction pathways, which regulate actin organization, exocytosis, cell cycle progression, and phagocytosis.

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Year: 2000 PMID： 10992524 PMCID： PMC101576 DOI： 10.1128/IAI.68.10.6066-6068.2000

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

14 in total

1. The Rho GTPase Rho3 has a direct role in exocytosis that is distinct from its role in actin polarity.

Authors: J E Adamo; G Rossi; P Brennwald
Journal: Mol Biol Cell Date: 1999-12 Impact factor: 4.138

2. The N-terminal domain of Pseudomonas aeruginosa exoenzyme S is a GTPase-activating protein for Rho GTPases.

Authors: U M Goehring; G Schmidt; K J Pederson; K Aktories; J T Barbieri
Journal: J Biol Chem Date: 1999-12-17 Impact factor: 5.157

3. The amino-terminal domain of Pseudomonas aeruginosa ExoS disrupts actin filaments via small-molecular-weight GTP-binding proteins.

Authors: K J Pederson; A J Vallis; K Aktories; D W Frank; J T Barbieri
Journal: Mol Microbiol Date: 1999-04 Impact factor: 3.501

Review 4. Ras-related GTPases and the cytoskeleton.

Authors: A Hall
Journal: Mol Biol Cell Date: 1992-05 Impact factor: 4.138

5. Biochemical relationships between the 53-kilodalton (Exo53) and 49-kilodalton (ExoS) forms of exoenzyme S of Pseudomonas aeruginosa.

Authors: S Liu; T L Yahr; D W Frank; J T Barbieri
Journal: J Bacteriol Date: 1997-03 Impact factor: 3.490

6. Differential effect of Rac and Cdc42 on p38 kinase activity and cell cycle progression of nonadherent primary mouse fibroblasts.

Authors: A Philips; P Roux; V Coulon; J M Bellanger; A Vié; M L Vignais; J M Blanchard
Journal: J Biol Chem Date: 2000-02-25 Impact factor: 5.157

10. Vibrio parahaemolyticus inhibition of Rho family GTPase activation requires a functional chromosome I type III secretion system.

Authors: Timothy Casselli; Tarah Lynch; Carolyn M Southward; Bryan W Jones; Rebekah DeVinney
Journal: Infect Immun Date: 2008-03-17 Impact factor: 3.441

Pseudomonas aeruginosa ExoT is a Rho GTPase-activating protein.

1. The Rho GTPase Rho3 has a direct role in exocytosis that is distinct from its role in actin polarity.

2. The N-terminal domain of Pseudomonas aeruginosa exoenzyme S is a GTPase-activating protein for Rho GTPases.

3. The amino-terminal domain of Pseudomonas aeruginosa ExoS disrupts actin filaments via small-molecular-weight GTP-binding proteins.

Review 4. Ras-related GTPases and the cytoskeleton.

5. Biochemical relationships between the 53-kilodalton (Exo53) and 49-kilodalton (ExoS) forms of exoenzyme S of Pseudomonas aeruginosa.

6. Differential effect of Rac and Cdc42 on p38 kinase activity and cell cycle progression of nonadherent primary mouse fibroblasts.

7. Purification and characterization of exoenzyme S from Pseudomonas aeruginosa 388.

Review 8. The exoenzyme S regulon of Pseudomonas aeruginosa.

9. Cloning the structural gene for the 49-kDa form of exoenzyme S (exoS) from Pseudomonas aeruginosa strain 388.

10. Genetic relationship between the 53- and 49-kilodalton forms of exoenzyme S from Pseudomonas aeruginosa.

1. ExsE, a secreted regulator of type III secretion genes in Pseudomonas aeruginosa.

2. Regulatory role of PopN and its interacting partners in type III secretion of Pseudomonas aeruginosa.

3. Aeromonas salmonicida toxin AexT has a Rho family GTPase-activating protein domain.

4. Inactivation of small Rho GTPases by the multifunctional RTX toxin from Vibrio cholerae.

Review 5. Bacterial protein toxins that modify host regulatory GTPases.

6. The ADP ribosyltransferase domain of Pseudomonas aeruginosa ExoT contributes to its biological activities.

7. Epithelial cell polarity alters Rho-GTPase responses to Pseudomonas aeruginosa.

8. In vitro assays to monitor the activity of Pseudomonas aeruginosa Type III secreted proteins.

Review 9. Mechanisms of phagocytosis and host clearance of Pseudomonas aeruginosa.

10. Vibrio parahaemolyticus inhibition of Rho family GTPase activation requires a functional chromosome I type III secretion system.