| Literature DB >> 17229695 |
Magnus Monné1, Alan J Robinson, Christoph Boes, Michael E Harbour, Ian M Fearnley, Edmund R S Kunji.
Abstract
Members of the mitochondrial carrier family have been reported in eukaryotes only, where they transport metabolites and cofactors across the mitochondrial inner membrane to link the metabolic pathways of the cytosol and the matrix. The genome of the giant virus Mimiviridae mimivirus encodes a member of the mitochondrial carrier family of transport proteins. This viral protein has been expressed in Lactococcus lactis and is shown to transport dATP and dTTP. As the 1.2-Mb double-stranded DNA mimivirus genome is rich in A and T residues, we speculate that the virus is using this protein to target the host mitochondria as a source of deoxynucleotides for its replication.Entities:
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Year: 2007 PMID: 17229695 PMCID: PMC1866048 DOI: 10.1128/JVI.02386-06
Source DB: PubMed Journal: J Virol ISSN: 0022-538X Impact factor: 5.103