Literature DB >> 17228883

Synthesis and antimalarial activity of side chain modified 4-aminoquinoline derivatives.

V Raja Solomon1, W Haq, Kumkum Srivastava, Sunil K Puri, S B Katti.   

Abstract

A new series of side-chain modified 4-aminoquinolines have been synthesized and found active against P. falciparum in vitro and P. yoelli in vivo. Compounds 6, 11, 12, and 19 exhibited superior in vitro activity compared to chloroquine. Selected compounds 6, 12, and 19 exhibited significant suppression in the in vivo assay. These analogs form a complex with hematin and inhibit the beta-hematin formation, suggesting that this class of compounds act on a heme polymerization target.

Entities:  

Mesh：

Substances：

Year:  2007        PMID： 17228883     DOI： 10.1021/jm061002i

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  17 in total

1.  Synthesis, Antiplasmodial Activity, and β-Hematin Inhibition of Hydroxypyridone-Chloroquine Hybrids.

Authors:  Warren A Andayi; Timothy J Egan; Jiri Gut; Philip J Rosenthal; Kelly Chibale
Journal:  ACS Med Chem Lett       Date:  2013-05-20       Impact factor: 4.345

Review 2.  Malarial hemozoin: from target to tool.

Authors:  Lorena M Coronado; Christopher T Nadovich; Carmenza Spadafora
Journal:  Biochim Biophys Acta       Date:  2014-02-17

3.  4-(Pyrimidin-2-yl)-1-thia-4-aza-spiro-[4.5]decan-3-one.

Authors:  Patrícia D Neuenfeldt; Bruna B Drawanz; Wilson Cunico; Edward R T Tiekink; James L Wardell; Solange M S V Wardell
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-11-25

4.  Synthesis of 4-aminoquinoline-pyrimidine hybrids as potent antimalarials and their mode of action studies.

Authors:  Kamaljit Singh; Hardeep Kaur; Kelly Chibale; Jan Balzarini
Journal:  Eur J Med Chem       Date:  2013-06-10       Impact factor: 6.514

5.  Synthesis and Evaluation of Chirally Defined Side Chain Variants of 7-Chloro-4-Aminoquinoline To Overcome Drug Resistance in Malaria Chemotherapy.

Authors:  Vasantha Rao Dola; Awakash Soni; Pooja Agarwal; Hafsa Ahmad; Kanumuri Siva Rama Raju; Mamunur Rashid; Muhammad Wahajuddin; Kumkum Srivastava; W Haq; A K Dwivedi; S K Puri; S B Katti
Journal:  Antimicrob Agents Chemother       Date:  2017-02-23       Impact factor: 5.191

6.  Synthesis, Biological Evaluation, and Molecular Modeling Studies of Chiral Chloroquine Analogues as Antimalarial Agents.

Authors:  Srinivasarao Kondaparla; Utsab Debnath; Awakash Soni; Vasantha Rao Dola; Manish Sinha; Kumkum Srivastava; Sunil K Puri; Seturam B Katti
Journal:  Antimicrob Agents Chemother       Date:  2018-11-26       Impact factor: 5.191

7.  Structural modifications of quinoline-based antimalarial agents: Recent developments.

Authors:  Sandhya Bawa; Suresh Kumar; Sushma Drabu; Rajiv Kumar
Journal:  J Pharm Bioallied Sci       Date:  2010-04

8.  3-(2H-1,3-Benzodioxol-5-ylmeth-yl)-2-(2-meth-oxy-phen-yl)-1,3-thia-zolidin-4-one.

Authors:  Victor Facchinetti; Claudia R B Gomes; Wilson Cunico; Solange M S V Wardell; James L Wardell; Edward R T Tiekink
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-10-22

9.  Antiplasmodial activity of chloroquine analogs against chloroquine-resistant parasites, docking studies and mechanisms of drug action.

Authors:  Nicolli B de Souza; Arturene M L Carmo; Adilson D da Silva; Tanos C C França; Antoniana U Krettli
Journal:  Malar J       Date:  2014-12-02       Impact factor: 2.979

10.  (2E)-4-(4-Bromo-phen-yl)-2-{(2Z)-[1-(4-methyl-phen-yl)ethyl-idene]hydrazinyl-idene}-3-phenyl-2,3-di-hydro-1,3-thia-zole.

Authors:  Shaaban K Mohamed; Mehmet Akkurt; Joel T Mague; Alaa A Hassan; Mustafa R Albayati
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2013-09-18
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.