OBJECTIVE: Motivated by inconsistent literature, we evaluated the association between incident pancreatic cancer and reproductive characteristics. DESIGN: The Iowa Women's Health Study is a large prospective population-based cohort followed from 1986 to 2003. Reproductive information was self-reported. PARTICIPANTS: The study population comprised 37,459 women aged 55-69 years at baseline. Over 18 years, 228 incident pancreatic cancers were identified. RESULTS: In a multivariate-adjusted model there were no associations between incident pancreatic cancer and age at first birth, number of births, age at menarche, or use of hormones. There was a statistically significant inverse association between age at menopause and pancreatic cancer incidence. Compared to menopause less than 45 years, the hazard ratio of pancreatic cancer was 0.61 (95% CI, 0.40-0.94) for menopause at 45-49 years, 0.75 (95% CI, 0.51-1.09) for 50-54 years, and 0.35 (95% CI, 0.18-0.68) for menopause at 55 years or more (P trend=0.005). This association held after restricting the cohort to never smokers. The associations between pancreatic cancer and ages at natural and surgical menopause followed similar patterns. In a parallel fashion, risk of pancreatic cancer was decreased for women with intact ovaries compared to those who had oophorectomy: hazard ratio was 0.70 (95% CI, 0.50-0.99). CONCLUSIONS: Our results indicate that older age at menopause is associated with reduced pancreatic cancer risk, but further research is warranted.
OBJECTIVE: Motivated by inconsistent literature, we evaluated the association between incident pancreatic cancer and reproductive characteristics. DESIGN: The Iowa Women's Health Study is a large prospective population-based cohort followed from 1986 to 2003. Reproductive information was self-reported. PARTICIPANTS: The study population comprised 37,459 women aged 55-69 years at baseline. Over 18 years, 228 incident pancreatic cancers were identified. RESULTS: In a multivariate-adjusted model there were no associations between incident pancreatic cancer and age at first birth, number of births, age at menarche, or use of hormones. There was a statistically significant inverse association between age at menopause and pancreatic cancer incidence. Compared to menopause less than 45 years, the hazard ratio of pancreatic cancer was 0.61 (95% CI, 0.40-0.94) for menopause at 45-49 years, 0.75 (95% CI, 0.51-1.09) for 50-54 years, and 0.35 (95% CI, 0.18-0.68) for menopause at 55 years or more (P trend=0.005). This association held after restricting the cohort to never smokers. The associations between pancreatic cancer and ages at natural and surgical menopause followed similar patterns. In a parallel fashion, risk of pancreatic cancer was decreased for women with intact ovaries compared to those who had oophorectomy: hazard ratio was 0.70 (95% CI, 0.50-0.99). CONCLUSIONS: Our results indicate that older age at menopause is associated with reduced pancreatic cancer risk, but further research is warranted.
Authors: Eunjung Lee; Pamela L Horn-Ross; Rudolph P Rull; Susan L Neuhausen; Hoda Anton-Culver; Giske Ursin; Katherine D Henderson; Leslie Bernstein Journal: Am J Epidemiol Date: 2013-09-05 Impact factor: 4.897
Authors: Leila Lujan-Barroso; Wei Zhang; Sara H Olson; Yu-Tang Gao; Herbert Yu; Peter A Baghurst; Paige M Bracci; H Bas Bueno-de-Mesquita; Lenka Foretová; Steven Gallinger; Ivana Holcatova; Vladimír Janout; Bu-Tian Ji; Robert C Kurtz; Carlo La Vecchia; Pagona Lagiou; Donghui Li; Anthony B Miller; Diego Serraino; Witold Zatonski; Harvey A Risch; Eric J Duell Journal: Pancreas Date: 2016-11 Impact factor: 3.327
Authors: Yuqing Zhang; Patricia F Coogan; Julie R Palmer; Brian L Strom; Lynn Rosenberg Journal: Cancer Causes Control Date: 2009-11-26 Impact factor: 2.506
Authors: Richard J Stevens; Andrew W Roddam; Jane Green; Kirstin Pirie; Diana Bull; Gillian K Reeves; Valerie Beral Journal: Cancer Epidemiol Biomarkers Prev Date: 2009-05 Impact factor: 4.254