Literature DB >> 1722475

Genes for insulin-like growth factors I and II are expressed in senescent rat tissues.

G H Park1, D E Buetow.   

Abstract

Insulin-like growth factor IGF-I and IGF-II gene expression was measured for the first time in rat liver, brain and heart during the later stages of life, i.e., young adulthood (6 months) to senescence (25 months). IGF-I mRNA was detected in all three tissues at all ages. Its relative level decreased the most in the liver with advancing age. IGF-II mRNA was detected in the brain and heart but not the liver at all ages. The level of IGF-II mRNA decreased only slightly in the brain from young adulthood to senescence.

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Year:  1991        PMID： 1722475     DOI： 10.1159/000213278

Source DB:  PubMed          Journal:  Gerontology        ISSN： 0304-324X            Impact factor:   5.140


  9 in total

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2.  E4BP4 is a cardiac survival factor and essential for embryonic heart development.

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4.  Decreased proliferative capacity of aged dermal fibroblasts in a three dimensional matrix is associated with reduced IGF1R expression and activation.

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Review 6.  Senescence-messaging secretome: SMS-ing cellular stress.

Authors:  Thomas Kuilman; Daniel S Peeper
Journal:  Nat Rev Cancer       Date:  2009-01-09       Impact factor: 60.716

7.  Hypertrophy of cultured adult rat ventricular cardiomyocytes induced by antibodies against the insulin-like growth factor (IGF)-I or the IGF-I receptor is IGF-II-dependent.

Authors:  Chih-Yang Huang; Ling-Yang Hao; Dennis E Buetow
Journal:  Mol Cell Biochem       Date:  2002-04       Impact factor: 3.396

8.  Insulin-like growth factor 2 rescues aging-related memory loss in rats.

Authors:  Adam B Steinmetz; Sarah A Johnson; Dylan E Iannitelli; Gabriella Pollonini; Cristina M Alberini
Journal:  Neurobiol Aging       Date:  2016-04-21       Impact factor: 4.673

9.  Tanshinone IIA Inhibits β-Catenin Nuclear Translocation and IGF-2R Activation via Estrogen Receptors to Suppress Angiotensin II-Induced H9c2 Cardiomyoblast Cell Apoptosis.

Authors:  Ya-Fang Chen; Cecilia Hsuan Day; Nien-Hung Lee; Yu-Feng Chen; Jaw-Ji Yang; Chih-Hsueh Lin; Ray-Jade Chen; Peramaiyan Rajendran; Vijaya Padma Viswanadha; Chih-Yang Huang
Journal:  Int J Med Sci       Date:  2017-09-30       Impact factor: 3.738
  9 in total

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