The effects of menopause on the serum lipid profile of normal females of South East Nigeria.

Dyslipidemia in menopause is a known feature in women, whether it leads to significant increase in the development of coronary heart disease (CHD) is still controversial, more so in our environment where little work has been done. The present study is aimed at comparing the level of total serum cholesterol, including its subunits in premenopausal with that of their postmenopausal counterparts. This is to enable us ascertain the relative risk of developing cardiovascular disease in postmenopausal women in our environment. One hundred and twenty six (126) apparently healthy, non-pregnant females (74 premenopausal and 52 postmenopausal) were recruited for the study. Serum total cholesterol and their subfractions- high-density lipoproteins (HDL), low-density lipoproteins (LDL), very low-density lipoproteins (VLDL) and triglycerides (TG) were estimated using enzymatic and established mathematical methods. There was no significant difference in the total serum cholesterol and triglyceride between the two groups. There was however, a significant reduction of HDL and VLDL in the postmenopausal group [P < 0.005] and a significant increase in the level of LDL in the postmenopausal group [P < 0.005]). The elevated LDL and the reduction of cardio protective HDL and VLDL is an indication that menopause is an independent risk factor for developing cardiovascular disease in our environment.